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Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using SGLT2 Polyclonal antibody (24654-1-AP)

    WB analysis using 24654-1-AP (same clone as 24654-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 24654-1-AP (SGLT2 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 24654-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of A549 cells using SGLT2 Polyclonal antibody (24654-1-AP)

    WB analysis of A549 using 24654-1-AP (same clone as 24654-1-PBS)

    A549 cells were subjected to SDS PAGE followed by western blot with 24654-1-AP (SGLT2 antibody at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 24654-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of various lysates using SGLT2 Polyclonal antibody (24654-1-AP)

    WB analysis using 24654-1-AP (same clone as 24654-1-PBS)

    Rat kidney tissue were subjected to SDS PAGE followed by western blot with 24654-1-AP (SGLT2 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 24654-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human kidney tissue using SGLT2 Polyclonal antibody (24654-1-AP)

    IHC staining of human kidney using 24654-1-AP (same clone as 24654-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 24654-1-AP (SGLT2 antibody at dilution of 1:200 (under 10x lens). This data was developed using the same antibody clone with 24654-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human kidney tissue using SGLT2 Polyclonal antibody (24654-1-AP)

    IHC staining of human kidney using 24654-1-AP (same clone as 24654-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 24654-1-AP (SGLT2 antibody at dilution of 1:200 (under 40x lens). This data was developed using the same antibody clone with 24654-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of rat kidney tissue using SGLT2 Polyclonal antibody (24654-1-AP)

    IHC staining of rat kidney using 24654-1-AP (same clone as 24654-1-PBS)

    Immunohistochemical analysis of paraffin-embedded rat kidney tissue slide using 24654-1-AP (SGLT2 antibody) at dilution of 1:400 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 24654-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human kidney tissue using SGLT2 Polyclonal antibody (24654-1-AP)

    IHC staining of human kidney using 24654-1-AP (same clone as 24654-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 24654-1-AP (SGLT2 antibody) at dilution of 1:400 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 24654-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human kidney tissue using SGLT2 Polyclonal antibody (24654-1-AP)

    IHC staining of human kidney using 24654-1-AP (same clone as 24654-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 24654-1-AP (SGLT2 antibody at dilution of 1:200 (under 10x lens). This data was developed using the same antibody clone with 24654-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human kidney tissue using SGLT2 Polyclonal antibody (24654-1-AP)

    IHC staining of human kidney using 24654-1-AP (same clone as 24654-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 24654-1-AP (SGLT2 antibody at dilution of 1:200 (under 40x lens). This data was developed using the same antibody clone with 24654-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of rat kidney tissue using SGLT2 Polyclonal antibody (24654-1-AP)

    IHC staining of rat kidney using 24654-1-AP (same clone as 24654-1-PBS)

    Immunohistochemical analysis of paraffin-embedded rat kidney tissue slide using 24654-1-AP (SGLT2 antibody) at dilution of 1:400 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 24654-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of mouse kidney tissue using SGLT2 Polyclonal antibody (24654-1-AP)

    IF Staining of mouse kidney using 24654-1-AP (same clone as 24654-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded mouse kidney tissue using SGLT2 antibody (24654-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 24654-1-PBS in a different storage buffer formulation.

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  • Featured Product
  • KD/KO Validated

SGLT2 Polyclonal antibody, PBS Only

SGLT2 Polyclonal Antibody for WB, IHC, IF-P, ELISA
Cat No. 24654-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IHC, IF-P, ELISA

Synonyms

SLC5A2, Na(+)/glucose cotransporter 2, Low affinity sodium-glucose cotransporter

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

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Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

24654-1-PBS targets SGLT2 in WB, IHC, IF-P, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen SGLT2 fusion protein Ag19163 相同性解析による交差性が予測される生物種
Full Name solute carrier family 5 (sodium/glucose cotransporter), member 2
Calculated molecular weight 672 aa, 73 kDa
Observed molecular weight 69-70 kDa
GenBank accession numberBC131542
Gene Symbol SGLT2
Gene ID (NCBI) 6524
RRIDAB_2750601
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDP31639
Storage Buffer PBS only , pH 7.3
Storage ConditionsStore at -80°C.

Background Information

Sodium-glucose cotransporter 2 (SGLT2), encoded by SLC5A2, utilizes the electrochemical sodium gradient to transport glucose against the cell's internal concentration gradient. Mainly expressed on brush border membrane (BBM) of epithelial cells in the early segment of the proximal tubule, SGLT2 mediates most of the glucose reabsorption by the kidney overall. Inhibition of SGLT2 could improve glucose homeostasis of diabetic patients, which has been considered as a novel strategy for diabetes treatment.