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Target

Host

Species Reactivity

Species Reactivity

Conjugate

Conjugate

Anti-Human SLAMF7/CD319 Rabbit Recombinant Antibody, PBS Only

SLAMF7/CD319 Recombinant Antibody for FC

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Conjugate

Unconjugated

CloneNo.

241321F11

Cat no : 98093-1-PBS

Synonyms

SLAMF7, FOAP-12, CS1, CRACC, CD319

Validation Data Gallery

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  • Flow cytometry (FC) experiment of human PBMCs using Anti-Human SLAMF7/CD319 Rabbit Recombinant Antibod (98093-1-RR)

    FC experiment of human PBMCs using 98093-1-RR (same clone as 98093-1-PBS)

    1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human SLAMF7/CD319 Rabbit Recombinant Antibody (98093-1-RR, Clone:241321F11) or 0.25 ug Isotype Control, and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were then stained with APC Anti-Human CD3. Cells were not fixed. Lymphocytes were gated. This data was developed using the same antibody clone with 98093-1-PBS in a different storage buffer formulation.

  • Flow cytometry (FC) experiment of human PBMCs using Anti-Human SLAMF7/CD319 Rabbit Recombinant Antibod (98093-1-RR)

    FC experiment of human PBMCs using 98093-1-RR (same clone as 98093-1-PBS)

    1x10^6 human PBMCs were surface stained with 0.25 ug Anti-Human SLAMF7/CD319 Rabbit Recombinant Antibody (98093-1-RR, Clone:241321F11) (red) or 0.25 ug Isotype Control (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. Lymphocytes were gated. This data was developed using the same antibody clone with 98093-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98093-1-RR

    Affinity and Kinetic Characterization of 98093-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98093-1-RR against Human SLAMF7/CD319 were performed. The affinity constant is 0.634 nM.

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Tested Applications

Recommended dilution

ApplicationDilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

98093-1-PBS targets SLAMF7/CD319 in FC applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen Recombinant Protein 相同性解析による交差性が予測される生物種
Full Name SLAM family member 7
Calculated molecular weight 335 aa, 37 kDa
GenBank accession numberBC027867
Gene symbol SLAMF7
Gene ID (NCBI) 57823
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Signaling lymphocyte activation molecule (SLAM) family receptors is a group of type I transmembrane receptors belonging to the immunoglobulin superfamily (PMID: 37251372). The SLAM family contains nine members that contain an extracellular segment comprising two or four Ig-like domains (V-like variable and C2-like constant), a transmembrane region and a cytoplasmic tail (PMID: 29662641). They are involved in various physiological and pathological processes, including the regulation of immunological responses and the route of viral entry. SLAMF7, also known as CS1, CRACC or CD319, is expressed on NK cells, CD8+ T lymphocytes, B lymphocytes, and mature dendritic cells (PMID: 28861320). It exerts both activating and inhibitory effects depending on the expression status of SAP or EAT-2. SLAMF7 is overexpressed in multiple myeloma and makes it a target for immunotherapy (PMID: 28861320).