SLC7A5 Recombinant antibody, PBS Only
SLC7A5 Recombinant Antibody for WB, FC (Intra), Indirect ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human
Applications
WB, FC (Intra), Indirect ELISA
Conjugate
Unconjugated
CloneNo.
241476D5
Cat no : 84178-5-PBS
Synonyms
Validation Data Gallery
Tested Applications
Recommended dilution
Application | Dilution |
---|---|
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. |
Product Information
The immunogen of 84178-5-PBS is SLC7A5 Fusion Protein expressed in E. coli.
Tested Reactivity | human |
Host / Isotype | Rabbit / IgG |
Class | Recombinant |
Type | Antibody |
Immunogen | SLC7A5 fusion protein Ag29164 相同性解析による交差性が予測される生物種 |
Full Name | solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 |
Calculated molecular weight | 507 aa, 55 kDa |
Observed molecular weight | 35-40 kDa |
GenBank accession number | BC039692 |
Gene symbol | SLC7A5 |
Gene ID (NCBI) | 8140 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purfication |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
Large neutral amino acid transporter 1 LAT1(also named as SLC7A5) is a sodium- and pH-independent transporter that supplies essential amino acids (e.g., leucine, phenylalanine) to cells. It plays an important role in the blood-brain barrier (BBB), where it facilitates the transport of thyroid hormones, drugs (e.g., l-DOPA, gabapentin), and metabolites to the brain. In addition, its expression is highly upregulated in various types of human cancers, which are characterized by a high demand for amino acids for growth and proliferation. The LAT1 subunit in humans is a 507 amino acid-long polypeptide with a theoretical molecular mass of 55 kDa. The protein is hydrophobic and is predicted to be constituted by 12 transmembrane segments. The apparent molecular mass of the proteins diminished to approximately 35 - 40 kDa.(PMID: 23912240 ;PMID: 26256001)