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Target

Host

Species Reactivity

Species Reactivity

Conjugate

Conjugate

SORLA Monoclonal antibody

SORLA Monoclonal Antibody for WB, IF-P, ELISA

Host / Isotype

Mouse / IgG1

Reactivity

human

Applications

WB, IF-P, ELISA

Conjugate

Unconjugated

CloneNo.

2E7D9

Cat no : 68651-1-Ig

Synonyms

SORL1, SORL 1, Low-density lipoprotein receptor relative with 11 ligand-binding repeats, LDLR relative with 11 ligand-binding repeats, C11orf32

Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using SORL1 Monoclonal antibody (68651-1-Ig)

    WB analysis using 68651-1-Ig

    Various lysates were subjected to SDS PAGE followed by western blot with 68651-1-Ig (SORL1 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours.

  • Immunofluorescence (IF) / fluorescent staining of mouse cerebellum tissue using SORL1 Monoclonal antibody (68651-1-Ig)

    IF Staining of mouse cerebellum using 68651-1-Ig

    Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded mouse cerebellum tissue using SORL1 antibody (68651-1-Ig, Clone: 2E7D9 ) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Mouse IgG(H+L) (SA00013-1). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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Tested Applications

Positive WB detected inLNCaP cells
Positive IF-P detected inmouse cerebellum tissue

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:1000-1:4000
Immunofluorescence (IF)-PIF-P : 1:200-1:800
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

68651-1-Ig targets SORLA in WB, IF-P, ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen SORLA fusion protein Ag18445 相同性解析による交差性が予測される生物種
Full Name sortilin-related receptor, L(DLR class) A repeats-containing
Calculated molecular weight 2214 aa, 248 kDa
Observed molecular weight 300 kDa
GenBank accession numberBC137171
Gene symbol SORLA
Gene ID (NCBI) 6653
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

SorLA also known as SorL1 or LR11, is a multiligand receptor belonging to the LDL receptor superfamily. It is also a member of vacuolar protein sorting-10 (Vps10) family and is enriched in the brain. SorLA acts as an sorting receptor for APP and prevents amyloidogenic processing of APP. Downregulation of SorLA has been found in patients with sporadic Alzheimer disease (AD). Currently SorLA has emerged as a potential target for AD therapy. (25404298)

Protocols

Product Specific Protocols
WB protocol for SORLA antibody 68651-1-IgDownload protocol
IF protocol for SORLA antibody 68651-1-IgDownload protocol
Standard Protocols
Click here to view our Standard Protocols