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  • Featured Product
  • KD/KO Validated

SORLA Polyclonal antibody, PBS Only

SORLA Polyclonal Antibody for WB, IHC, IF-P, IP, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IHC, IF-P, IP, Indirect ELISA

Conjugate

Unconjugated

Cat no : 22592-1-PBS

Synonyms

Validation Data Gallery

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  • Western Blot (WB) analysis of mouse brain tissue using SORLA Polyclonal antibody (22592-1-AP)

    WB analysis of mouse brain using 22592-1-AP (same clone as 22592-1-PBS)

    mouse brain tissue were subjected to SDS PAGE followed by western blot with 22592-1-AP (SORLA antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 22592-1-PBS in a different storage buffer formulation.

  • Immunoprecipitation (IP) experiment of mouse brain tissue using SORLA Polyclonal antibody (22592-1-AP)

    IP experiment of mouse brain using 22592-1-AP (same clone as 22592-1-PBS)

    IP result of anti-SORLA (IP:22592-1-AP, 5ug; Detection:22592-1-AP 1:500) with mouse brain tissue lysate 10000ug. This data was developed using the same antibody clone with 22592-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of mouse brain tissue using SORLA Polyclonal antibody (22592-1-AP)

    IHC staining of mouse brain using 22592-1-AP (same clone as 22592-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 22592-1-AP (SORLA antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 22592-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of mouse brain tissue using SORLA Polyclonal antibody (22592-1-AP)

    IHC staining of mouse brain using 22592-1-AP (same clone as 22592-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 22592-1-AP (SORLA antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 22592-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human brain tissue using SORLA Polyclonal antibody (22592-1-AP)

    IHC staining of human brain using 22592-1-AP (same clone as 22592-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human brain slide using 22592-1-AP (SORLA antibody at dilution of 1:50. This data was developed using the same antibody clone with 22592-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human brain tissue using SORLA Polyclonal antibody (22592-1-AP)

    IHC staining of human brain using 22592-1-AP (same clone as 22592-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human brain slide using 22592-1-AP (SORLA antibody at dilution of 1:50. This data was developed using the same antibody clone with 22592-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of rat brain tissue using SORLA Polyclonal antibody (22592-1-AP)

    IHC staining of rat brain using 22592-1-AP (same clone as 22592-1-PBS)

    Immunohistochemical analysis of paraffin-embedded rat brain tissue slide using 22592-1-AP (SORLA antibody at dilution of 1:50 (under 10x lens). This data was developed using the same antibody clone with 22592-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of rat brain tissue using SORLA Polyclonal antibody (22592-1-AP)

    IHC staining of rat brain using 22592-1-AP (same clone as 22592-1-PBS)

    Immunohistochemical analysis of paraffin-embedded rat brain tissue slide using 22592-1-AP (SORLA antibody at dilution of 1:50 (under 40x lens). This data was developed using the same antibody clone with 22592-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of mouse cerebellum tissue using SORLA Polyclonal antibody (22592-1-AP)

    IF Staining of mouse cerebellum using 22592-1-AP (same clone as 22592-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded mouse cerebellum tissue using SORLA antibody (22592-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L) (SA00013-2). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 22592-1-PBS in a different storage buffer formulation.

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Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

22592-1-PBS targets SORLA in WB, IHC, IF-P, IP, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen SORLA fusion protein Ag18445 相同性解析による交差性が予測される生物種
Full Name sortilin-related receptor, L(DLR class) A repeats-containing
Calculated molecular weight 2214 aa, 248 kDa
Observed molecular weight 300 kDa
GenBank accession numberBC137171
Gene symbol SORLA
Gene ID (NCBI) 6653
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen Affinity purified
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

SorLA also known as SorL1 or LR11, is a multiligand receptor belonging to the LDL receptor superfamily. It is also a member of vacuolar protein sorting-10 (Vps10) family and is enriched in the brain. SorLA acts as an sorting receptor for APP and prevents amyloidogenic processing of APP. Downregulation of SorLA has been found in patients with sporadic Alzheimer disease (AD). Currently SorLA has emerged as a potential target for AD therapy. (25404298)