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STAT2 Recombinant antibody

STAT2 Uni-rAbTM Recombinant Antibody for WB, ELISA
Cat No. 80061-5-RR
Clone No.242685A1

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, ELISA

STAT113, STAT 2, P113, ISGF3, ISGF 3

Formulation:  PBS and Azide
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Unconjugated
Size/Concentration:  100 μL, 1000 μg/ml
20 μL, 1000 μg/ml
100 μL, 1000 μg/ml

¥85,000/ 100 μL

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国内在庫・納期について

約2万点のプロテインテック製品をコスモバイオ社物流センター(国内)に在庫しています。国内在庫の有無はコスモバイオ社ホームページの「品番検索」でカタログ番号を検索して確認できます。


保証・サポートについて

テクニカルサポートまたはご購入後1年間の交換/補填対応を承ります。詳細はこちらをご覧ください。


Tested Applications

Positive WB detected inA549 cells, HeLa cells, A431 cells

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:5000-1:50000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

80061-5-RR targets STAT2 in WB, ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen STAT2 fusion protein Ag10168 相同性解析による交差性が予測される生物種
Full Name signal transducer and activator of transcription 2, 113kDa
Calculated molecular weight 851 aa, 98 kDa
Observed molecular weight110 kDa
GenBank accession numberBC051284
Gene Symbol STAT2
Gene ID (NCBI) 6773
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDP52630
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol , pH 7.3
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

STAT2, also named as p113, belongs to the transcription factor STAT family. It is a signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IF stimulated genes, which drive the cell in an antiviral state. It also interacts with CRSP2, CRSP6, Simian virus 5 protein V, rabies virus phosphoprotein, IFNAR1 and IFNAR2. Its interaction with dengue virus NS5 inhibits the phosphorylation of STAT2, and, when all viral proteins are present (polyprotein), STAT2 is targeted for degradation. The calculated molecular weight of STAT2 is 98 kDa, but phosphorylated STAT2 is about 100-113 kDa.

Protocols

Product Specific Protocols
WB protocol for STAT2 antibody 80061-5-RRDownload protocol
Standard Protocols
Click here to view our Standard Protocols
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