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Target

Host

Species Reactivity

Species Reactivity

Conjugate

Conjugate

TACSTD2/TROP2 Monoclonal antibody, PBS Only

TACSTD2/TROP2 Monoclonal Antibody for WB, IHC, IF/ICC, Indirect ELISA

Host / Isotype

Mouse / IgG2b

Reactivity

Human

Applications

WB, IHC, IF/ICC, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

5A6B1

Cat no : 68141-1-PBS

Synonyms

EGP 1, GA733, GA733 1, M1S1, TACSTD2, TROP2

Validation Data Gallery

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  • Western Blot (WB) analysis of HaCaT cells using TACSTD2/TROP2 Monoclonal antibody (68141-1-Ig)

    WB analysis of HaCaT using 68141-1-Ig (same clone as 68141-1-PBS)

    HaCaT cells were subjected to SDS PAGE followed by western blot with 68141-1-Ig (TACSTD2/TROP2 antibody) at dilution of 1:2500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68141-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human breast cancer tissue using TACSTD2/TROP2 Monoclonal antibody (68141-1-Ig)

    IHC staining of human breast cancer using 68141-1-Ig (same clone as 68141-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 68141-1-Ig (TACSTD2/TROP2 antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 68141-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human breast cancer tissue using TACSTD2/TROP2 Monoclonal antibody (68141-1-Ig)

    IHC staining of human breast cancer using 68141-1-Ig (same clone as 68141-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 68141-1-Ig (TACSTD2/TROP2 antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 68141-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of HaCaT cells using TACSTD2/TROP2 Monoclonal antibody (68141-1-Ig)

    IF Staining of HaCaT using 68141-1-Ig (same clone as 68141-1-PBS)

    Immunofluorescent analysis of (-20°C Methanol) fixed HaCaT cells using TACSTD2/TROP2 antibody (68141-1-Ig, Clone: 5A6B1 ) at dilution of 1:800 and CoraLite®488-Conjugated Goat Anti-Mouse IgG(H+L). This data was developed using the same antibody clone with 68141-1-PBS in a different storage buffer formulation.

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Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

68141-1-PBS targets TACSTD2/TROP2 in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with Human samples.

Tested Reactivity Human
Host / Isotype Mouse / IgG2b
Class Monoclonal
Type Antibody
Immunogen TACSTD2/TROP2 fusion protein Ag25775 相同性解析による交差性が予測される生物種
Full Name tumor-associated calcium signal transducer 2
Calculated molecular weight 36 kDa
Observed molecular weight40-50 kDa
GenBank accession numberBC009409
Gene symbol TROP2
Gene ID (NCBI) 4070
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Trophoblast cell surface antigen 2 (TROP2), also named as TACSTD2, is a transmembrane glycoprotein. TROP2 plays a role in transducing intracellular calcium signals. It is expressed in trophoblast cells, cornea and multi-stratified epithelia. TROP2 is overexpressed in most carcinomas and is involved in cancer proliferation, migration, invasion, and metastasis. Congenital mutations of TROP2 cause a rare autosomal recessive disease which may lead to blindness-the gelatinous drop-like corneal disease (PMID: 35688908).