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Target

Host

Species Reactivity

Species Reactivity

Conjugate

Conjugate

TDO2 Recombinant antibody

TDO2 Recombinant Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

rat

Applications

WB, ELISA

Conjugate

Unconjugated

CloneNo.

240068C2

Cat no : 83236-2-RR

Synonyms

TDO, TDO2, TO, TPH2, TRPO, Tryptamin 2,3 dioxygenase, tryptophan 2,3 dioxygenase, Tryptophan oxygenase, Tryptophan pyrrolase, Tryptophanase

Validation Data Gallery

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  • Western Blot (WB) analysis of rat liver tissue using TDO2 Recombinant antibody (83236-2-RR)

    WB analysis of rat liver using 83236-2-RR

    rat liver tissue were subjected to SDS PAGE followed by western blot with 83236-2-RR (TDO2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours.

  • Affinity and Kinetic Characterization of 83236-2-RR

    Affinity and Kinetic Characterization of 83236-2-RR

    Biolayer interferometry (BLl) kinetic assays of 83236-2-RR against Human TDO2 were performed. The affinity constant is below 1 pM.

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Tested Applications

Positive WB detected inrat liver tissue

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:5000-1:50000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

83236-2-RR targets TDO2 in WB, ELISA applications and shows reactivity with rat samples.

Tested Reactivity rat
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen TDO2 fusion protein Ag8531 相同性解析による交差性が予測される生物種
Full Name tryptophan 2,3-dioxygenase
Calculated molecular weight 406 aa, 48 kDa
Observed molecular weight 40-50 kDa
GenBank accession numberBC005355
Gene symbol TDO2
Gene ID (NCBI) 6999
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

TDO2 (tryptophan 2,3-dioxygenase), IDO1 (indoleamine 2,3-dioxygenase 1) and IDO2 are three enzymes that catalyze the amino acid tryptophan into kynurenine in the kynurenine pathway (PMID: 23090118, 28469468). TDO2 plays an important role in neurological diseases such as Alzheimer's disease, Parkinson's disease and autism. Overexpression of TDO2 promoted tumor cell survival and was correlated with tumor grade and poor prognosis in triple negative breast cancer, brain tumors and esophageal squamous cell carcinoma. TDO2 may be a potential therapeutic target in some cancers. (PMID: 21976023, 30134247)

Protocols

Product Specific Protocols
WB protocol for TDO2 antibody 83236-2-RRDownload protocol
Standard Protocols
Click here to view our Standard Protocols