Validation Data Gallery
Tested Applications
Recommended dilution
| Application | Dilution |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
Published Applications
| WB | See 2 publications below |
Product Information
18994-1-AP targets TERT in WB, ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Cited Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide 相同性解析による交差性が予測される生物種 |
| Full Name | telomerase reverse transcriptase |
| Calculated molecular weight | 127 kDa |
| GenBank accession number | NM_198255 |
| Gene Symbol | TERT |
| Gene ID (NCBI) | 7015 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | O14746 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
Background Information
TERT,also named as EST2, TCS1 and TRT, belongs to the reverse transcriptase family and Telomerase subfamily. Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Activation of telomerase has been implicated in cell immortalization and cancer cell pathogenesis. TERT elongates telomeres by adding simple sequence repeats to chromosome ends. TERT can modulate Wnt signaling and plays important roles in aging and antiapoptosis. Mutation of TERT are associated with susceptibilty to aplastic anemia (AA), coronary artery disease (CAD), dyskeratosis congenita autosomal dominant (ADDKC) and idiopathic pulmonary fibrosis. Catalog#18994-1-AP is rabbit polyclonal antibody that can recognize all the 3 TERT isoforms.
Publications
| Species | Application | Title |
|---|---|---|
Cancer Med Acidified bile acids enhance tumor progression and telomerase activity of gastric cancer in mice dependent on c-Myc expression. | ||
Hepat Mon Targeting Human Telomerase Reverse Transcriptase by a Simple siRNA Expression Cassette in HepG2 Cells. |