Validation Data Gallery
Tested Applications
Recommended dilution
| Application | Dilution |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
Product Information
55307-1-AP targets TET1 in ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide 相同性解析による交差性が予測される生物種 |
| Full Name | tet oncogene 1 |
| Calculated molecular weight | 235 kDa |
| GenBank accession number | NM_030625 |
| Gene Symbol | TET1 |
| Gene ID (NCBI) | 80312 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q8NFU7 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| Storage Conditions | Store at -20°C. Aliquoting is unnecessary for -20oC storage. |
Background Information
TET1 ( also named CXXC6, KIAA1676 or LCX), belongs to the TET family (Tet1-3) which catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (hmC). TET1 binds throughout the genome of embryonic stem cells, with the majority of binding sites located at transcription start sites of CpG-rich promoters and within genes. Knockdown of Tet1 in preimplantation embryos resulted in a bias towards trophectoderm differentiation.Tet1 can associate with either active or repressed transcriptional states and be identified as new epigenetic factor implicated in the establishment and/or maintenance of a pluripotent epigenetic state during early embryonic development.Tet1 is highly expressed in ES cells and is rapidly downregulated upon differentiation. This antibody is specific to TET1.