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Target

Host

Species Reactivity

Species Reactivity

Conjugate

Conjugate

TGFBR3 Polyclonal antibody

TGFBR3 Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, ELISA

Conjugate

Unconjugated

Cat no : 28992-1-AP

Synonyms

TGF-beta receptor type 3, TGF-beta Receptor III, TGF beta receptor type III, TGF beta receptor type 3, BGCAN

Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using TGFBR3 Polyclonal antibody (28992-1-AP)

    WB analysis using 28992-1-AP

    Human placenta tissue was subjected to SDS PAGE followed by western blot with 28992-1-AP (TGFBR3 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours.

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Tested Applications

Positive WB detected inhuman placenta tissue

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:500-1:3000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

28992-1-AP targets TGFBR3 in WB, ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen TGFBR3 fusion protein Ag29397 相同性解析による交差性が予測される生物種
Full Name transforming growth factor, beta receptor III
Observed molecular weight130 kDa
GenBank accession numberBC136295
Gene symbol TGFBR3
Gene ID (NCBI) 7049
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

Transforming growth factor β (TGF-β) is a multifunctional cytokine that plays important roles in normal development and homeostasis (PMID: 8530052). There are three TGF-β forms: TGF-β1, TGF-β2, and TGF-β3. The diverse effects of TGF-β are mediated by the TGF-β receptors and cell surface-binding proteins. Three TGF-beta receptors exist: TGFBR1, TFGBR2, TGFBR3 (PMID: 8530052; 30184463). TGFBR3, also known as betaglycan, is a transmembrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. In addition to the transmembrane form, the extracellular domain of TGFBR3 can be cleaved to a soluble form (sTGFBR3), which may serve as an antagonist of TGF-β to inhibit TGF-β signaling (PMID: 30184463). TGFBR3 has a larger apparent molecular weight than the calculated molecular weight, due to extensive carbohydrate modifications (PMID: 1556106).

Protocols

Product Specific Protocols
WB protocol for TGFBR3 antibody 28992-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols