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Validation Data Gallery

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  • Western Blot (WB) analysis of HuH-7 cells using TIM-1 Recombinant antibody (84600-5-RR)

    WB analysis of HuH-7 using 84600-5-RR

    HuH-7 cells were subjected to SDS PAGE followed by western blot with 84600-5-RR (TIM-1 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours.

  • Affinity and Kinetic Characterization of 84600-5-RR

    Affinity and Kinetic Characterization of 84600-5-RR

    Biolayer interferometry (BLl) kinetic assays of 84600-5-RR against Human TIM-1 were performed. The affinity constant is 0.314 nM.

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TIM-1 Recombinant antibody

TIM-1 Recombinant Antibody for WB, ELISA
Cat No. 84600-5-RR
Clone No.242001D1

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, ELISA

Synonyms

HAVCR1, KIM-1, KIM1, HAVcr-1, CD365

Formulation:  PBS and Azide
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Unconjugated
Size/Concentration: 

-/ -

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テクニカルサポートまたはご購入後1年間の交換／補填対応を承ります。詳細はこちらをご覧ください。

Tested Applications

Positive WB detected inHuH-7 cells

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:1000-1:6000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

84600-5-RR targets TIM-1 in WB, ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen Recombinant protein 相同性解析による交差性が予測される生物種
Full Name hepatitis A virus cellular receptor 1
Calculated molecular weight39kDa
Observed molecular weight100 kDa
GenBank accession numberNM_001173393.3
Gene Symbol HAVCR1
Gene ID (NCBI) 26762
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDQ96D42
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol , pH 7.3
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

TIM-1, also known as kidney injury molecule (KIM-1), was first identified as a marker of acute kidney injury. TIM-1 mRNA and protein dramatically increase after ischemic kidney injury while there are low levels in normal kidneys. In addition, TIM-1 is expressed on CD4+ T cells after activation and its expression was sustained preferentially in Th2 but not Th1 cells. However, TIM-1 is expressed on both Th1 and Th2 cells and TIM-1 blockade prolongs survival of fully MHC-mismatched cardiac transplants. TIM-4, expressed by macrophages, is the ligand for TIM-1, and TIM-1 - TIM-4 interactions regulate Th cell responses and modulate Th1/Th2 cytokine balance. Moreover, TIM-1 can regulate macrophage activation and alter the co-stimulatory properties of macrophages. (PMID: 20091883)

Protocols

Product Specific Protocols
WB protocol for TIM-1 antibody 84600-5-RRDownload protocol
Standard Protocols
Click here to view our Standard Protocols