TIM3 Monoclonal antibody, PBS Only
TIM3 Monoclonal Antibody for WB, ELISA
Host / Isotype
Mouse / IgG1
Reactivity
human, pig, mouse, rat
Applications
WB, ELISA
Conjugate
Unconjugated
CloneNo.
4C4G3
Cat no : 60355-1-PBS
Synonyms
Validation Data Gallery
Tested Applications
Recommended dilution
Application | Dilution |
---|---|
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. |
Product Information
60355-1-PBS targets TIM3 in WB, ELISA applications and shows reactivity with human, pig, mouse, rat samples.
Tested Reactivity | human, pig, mouse, rat |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Immunogen | TIM3 fusion protein Ag16901 相同性解析による交差性が予測される生物種 |
Full Name | hepatitis A virus cellular receptor 2 |
Calculated molecular weight | 301 aa, 33 kDa |
Observed molecular weight | 33 kDa, 50-70 kDa |
GenBank accession number | BC020843 |
Gene symbol | TIM3 |
Gene ID (NCBI) | 84868 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
Storage Buffer | PBS only |
Storage Conditions | Store at -80°C. |
Background Information
TIM3, also known as HAVCR2, is a member of the recently discovered T cell Ig and mucin domain-containing molecule superfamily. TIM3 is a negative regulatory molecule that is important for T cell tolerance and has a crucial role in autoimmunity and T cell exhaustion during chronic viral infection (PMID: 23180819). TIM3 is expressed by T-helper type 1 (Th1) cells, macrophage, monocyte, dendritic cells, CD8+ T cell and other lymphocyte subsets. Galectin-9 is a ligand for TIM3. TIM3-galectin-9 pathway negatively regulates T helper type 1 immunity (PMID: 16286920). TIM3 is a 280-aa membrane protein with a calculated molecular weight of 33 kDa, the higher molecular weights between 50 and 70 kDa detected by this monoclonal antibody probably represent glycosylated TIM3 (PMID: 20107545; 17069754; 11725301).