- Featured Product
- KD/KO Validated
TMEM175 Monoclonal antibody, PBS Only
TMEM175 Monoclonal Antibody for WB, ELISA
Host / Isotype
Mouse / IgG1
Reactivity
human, mouse, rat, pig, rabbit
Applications
WB, ELISA
Conjugate
Unconjugated
CloneNo.
1E7E1
Cat no : 68172-1-PBS
Synonyms
Validation Data Gallery
Tested Applications
Recommended dilution
Application | Dilution |
---|---|
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. |
Product Information
68172-1-PBS targets TMEM175 in WB, ELISA applications and shows reactivity with human, mouse, rat, pig, rabbit samples.
Tested Reactivity | human, mouse, rat, pig, rabbit |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Immunogen | TMEM175 fusion protein Ag13890 相同性解析による交差性が予測される生物種 |
Full Name | transmembrane protein 175 |
Calculated molecular weight | 504 aa, 56 kDa |
Observed molecular weight | 55-60 kDa |
GenBank accession number | BC005158 |
Gene symbol | TMEM175 |
Gene ID (NCBI) | 84286 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
TMEM175 has two repeats of 6-transmembrane-spanning segments and has no GYG K+ channel sequence signature-containing, pore-forming P loop. Lysosomes lacking TMEM175 exhibit no K+conductance, have a markedly depolarized ΔΨ and little sensitivity to changes in [K+], and have compromised luminal pH stability and abnormal fusion with autophagosomes during autophagy. TMEM175 comprises a K+ channel that underlies the molecular mechanism of lysosomal K+ permeability.