TMPRSS6 Polyclonal antibody

TMPRSS6 Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IF, ELISA

Conjugate

Unconjugated

Cat no : 12950-1-AP

Synonyms

IRIDA, Matriptase 2, TMPRSS6


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Tested Applications

Positive WB detected inHEK-293 cells, HepG2 cells, MCF-7 cells, mouse liver tissue

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:500-1:1000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

12950-1-AP targets TMPRSS6 in WB, IF, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivityhuman, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen TMPRSS6 fusion protein Ag4076 相同性解析による交差性が予測される生物種
Full Name transmembrane protease, serine 6
Calculated molecular weight 89 kDa
Observed molecular weight 52 kDa
GenBank accession numberBC039082
Gene symbol TMPRSS6
Gene ID (NCBI) 164656
RRIDAB_2877896
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

The type II transmembrane serine protease TMPRSS6 (also known as matriptase-2) controls iron homeostasis through its negative regulation of expression of hepcidin, a key hormone involved in iron metabolism. Upstream of the hepcidin-regulated signaling pathway, TMPRSS6 cleaves its target substrate hemojuvelin (HJV) at the plasma membrane(PMID:21724843).It Belongs to the peptidase S1 family.Defects in TMPRSS6 are the cause of iron-refractory iron deficiency anemia (IRIDA).It has 4 isoforms produced by alternative splicing.

Protocols

Product Specific Protocols
WB protocol for TMPRSS6 antibody 12950-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
mouseWB

Haematologica

New thiazolidinones reduce iron overload in mouse models of hereditary hemochromatosis and β-thalassemia.

Authors - Jing Liu
human,mouseWB,IF

Cell Death Dis

Transmembrane serine protease 6, a novel target for inhibition of neuronal tumor growth

Authors - Yong Zuo
  • KD Validated