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Validation Data Gallery

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  • Western Blot (WB) analysis of human milk using Osteoprotegerin/TNFRSF11B Recombinant antibody (83506-1-RR)

    WB analysis of human milk using 83506-1-RR (same clone as 83506-1-PBS)

    human milk was subjected to SDS PAGE followed by western blot with 83506-1-RR (Osteoprotegerin/TNFRSF11B antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83506-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of rat kidney tissue using Osteoprotegerin/TNFRSF11B Recombinant antibody (83506-1-RR)

    IHC staining of rat kidney using 83506-1-RR (same clone as 83506-1-PBS)

    Immunohistochemical analysis of paraffin-embedded rat kidney tissue slide using 83506-1-RR (Osteoprotegerin/TNFRSF11B antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 83506-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of rat kidney tissue using Osteoprotegerin/TNFRSF11B Recombinant antibody (83506-1-RR)

    IHC staining of rat kidney using 83506-1-RR (same clone as 83506-1-PBS)

    Immunohistochemical analysis of paraffin-embedded rat kidney tissue slide using 83506-1-RR (Osteoprotegerin/TNFRSF11B antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 83506-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 83506-1-RR

    Affinity and Kinetic Characterization of 83506-1-RR

    Biolayer interferometry (BLl) kinetic assays of 83506-1 against Human Osteoprotegerin/ TNFRSF11B were performed. The affinity constant is below 1 pM.

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Osteoprotegerin/TNFRSF11B Recombinant antibody, PBS Only

Osteoprotegerin/TNFRSF11B Uni-rAbTM Recombinant Antibody for WB, IHC, ELISA
Cat No. 83506-1-PBS
Clone No.240168E9

Host / Isotype

Rabbit / IgG

Reactivity

human, rat

Applications

WB, IHC, ELISA

Synonyms

TNFRSF11B, Osteoprotegerin, Osteoclastogenesis inhibitory factor, OPG, OCIF

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

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Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

83506-1-PBS targets Osteoprotegerin/TNFRSF11B in WB, IHC, ELISA applications and shows reactivity with human, rat samples.

Tested Reactivity human, rat
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen Osteoprotegerin/TNFRSF11B fusion protein Ag2139 相同性解析による交差性が予測される生物種
Full Name tumor necrosis factor receptor superfamily, member 11b
Calculated molecular weight 401 aa, 46 kDa
Observed molecular weight56 kDa
GenBank accession numberBC030155
Gene Symbol TNFRSF11B
Gene ID (NCBI) 4982
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDO00300
Storage Buffer PBS only , pH 7.3
Storage ConditionsStore at -80°C.

Background Information

Osteoprotegerin (OPG), also known as tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) and osteoclastogenesis inhibitory factor (OCIF), belongs to the tumor necrosis factor (TNF) receptor superfamily. By binding to RANKL, OPG inhibits osteoclastic activity and promotes bone formation. OPG plays a key role in cell survival by inhibiting TRAIL-induced apoptosis. OPG also is involved in vascular biology, fibrosis, immunity, EMT, and the apoptosis of cancer cells (PMID: 35523775).