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Target

Host

Species Reactivity

Species Reactivity

Conjugate

Conjugate

TNFRSF17 Polyclonal antibody, PBS Only

TNFRSF17 Polyclonal Antibody for WB, IHC, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, IHC, Indirect ELISA

Conjugate

Unconjugated

Cat no : 27724-1-PBS

Synonyms

Validation Data Gallery

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  • Western Blot (WB) analysis of Daudi cells using TNFRSF17 Polyclonal antibody (27724-1-AP)

    WB analysis of Daudi using 27724-1-AP (same clone as 27724-1-PBS)

    Daudi and Ramos cells were subjected to SDS PAGE followed by western blot with 27724-1-AP (TNFRSF17 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 27724-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of Raji cells using TNFRSF17 Polyclonal antibody (27724-1-AP)

    WB analysis of Raji using 27724-1-AP (same clone as 27724-1-PBS)

    Raji cells were subjected to SDS PAGE followed by western blot with 27724-1-AP (TNFRSF17 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 27724-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of Ramos cells using TNFRSF17 Polyclonal antibody (27724-1-AP)

    WB analysis of Ramos using 27724-1-AP (same clone as 27724-1-PBS)

    Ramos cells were subjected to SDS PAGE followed by western blot with 27724-1-AP (TNFRSF17 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 27724-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human breast cancer tissue using TNFRSF17 Polyclonal antibody (27724-1-AP)

    IHC staining of human breast cancer using 27724-1-AP (same clone as 27724-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 27724-1-AP (TNFRSF17 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27724-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human breast cancer tissue using TNFRSF17 Polyclonal antibody (27724-1-AP)

    IHC staining of human breast cancer using 27724-1-AP (same clone as 27724-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using 27724-1-AP (TNFRSF17 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27724-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human tonsillitis tissue using TNFRSF17 Polyclonal antibody (27724-1-AP)

    IHC staining of human tonsillitis using 27724-1-AP (same clone as 27724-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 27724-1-AP (TNFRSF17 antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27724-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human tonsillitis tissue using TNFRSF17 Polyclonal antibody (27724-1-AP)

    IHC staining of human tonsillitis using 27724-1-AP (same clone as 27724-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 27724-1-AP (TNFRSF17 antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27724-1-PBS in a different storage buffer formulation.

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Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

27724-1-PBS targets TNFRSF17 in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen TNFRSF17 fusion protein Ag27049 相同性解析による交差性が予測される生物種
Full Name tumor necrosis factor receptor superfamily, member 17
Calculated molecular weight 184 aa, 20 kDa
Observed molecular weight 20 kDa
GenBank accession numberBC058291
Gene symbol TNFRSF17
Gene ID (NCBI) 608
RRIDAB_2880954
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

BCMA (B cell maturation antigen), also known as TNFRSF17, is 20.2-kDa type III transmembrane glycoprotein and is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes and plasma cells, which may be important for B cell development and autoimmune response (PMID: 32943087; 9846698). BCMA has two agonist ligands: a proliferation-inducing ligand (APRIL) and BAFF. When BCMA binds to APRIL, it transmits signals of cell survival and proliferation (PMID: 27127303); when BCMA binds to BAFF, it mediates the activation of NF-kappaB and MAPK8/JNK (PMID: 36140254). It has been found that the overexpression and activation of BCMA are associated with multiple myeloma (MM) in preclinical models and humans, supporting its potential utility as a therapeutic target for MM (PMID: 32055000; 32943087).