Validation Data Gallery
Tested Applications
Recommended dilution
Application | Dilution |
---|---|
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. |
Product Information
66498-1-PBS targets TRAF6 in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.
Tested Reactivity | human |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Immunogen | TRAF6 fusion protein Ag24696 相同性解析による交差性が予測される生物種 |
Full Name | TNF receptor-associated factor 6 |
Calculated molecular weight | 522 aa, 60 kDa |
Observed molecular weight | 60 kDa |
GenBank accession number | BC031052 |
Gene Symbol | TRAF6 |
Gene ID (NCBI) | 7189 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
UNIPROT ID | Q9Y4K3 |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
TRAF6 is a member of the TNF receptor associated factor (TRAF) protein family. TRAF6 is recognized as a signal transducer, which activates the NF-κB pathway in response to pro-inflammatory cytokines. TRAF6 has E3 ligase activity and is responsible for inducing Lys-63 (K63)-linked poly-ubiquitination chains, functioning together with E2 Ubc13/Uev1A complex to mediate IKK activation TRAF6 plays a crucial role in the regulation of the innate and adaptive immune responses.