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- KD/KO Validated
CoraLite® Plus 488-conjugated TRAF6 Monoclonal antibody
TRAF6 Monoclonal Antibody for
Host / Isotype
Mouse / IgG1
Reactivity
human, mouse
Applications
IF
Conjugate
CoraLite® Plus 488 Fluorescent Dye
CloneNo.
1D1E1
Cat no : CL488-66498
Synonyms
Validation Data Gallery
Tested Applications
Recommended dilution
Application | Dilution |
---|---|
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Sample-dependent, Check data in validation data gallery. |
Published Applications
IF | See 1 publications below |
Product Information
CL488-66498 targets TRAF6 in IF applications and shows reactivity with human, mouse samples.
Tested Reactivity | human, mouse |
Cited Reactivity | human |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Immunogen | TRAF6 fusion protein Ag24696 相同性解析による交差性が予測される生物種 |
Full Name | TNF receptor-associated factor 6 |
Calculated molecular weight | 522 aa, 60 kDa |
GenBank accession number | BC031052 |
Gene symbol | TRAF6 |
Gene ID (NCBI) | 7189 |
RRID | AB_2919334 |
Conjugate | CoraLite® Plus 488 Fluorescent Dye |
Excitation/Emission maxima wavelengths | 493 nm / 522 nm |
Form | Liquid |
Purification Method | Protein G purification |
Storage Buffer | PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3. |
Storage Conditions | Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
Background Information
TRAF6 is a member of the TNF receptor associated factor (TRAF) protein family. TRAF6 is recognized as a signal transducer, which activates the NF-κB pathway in response to pro-inflammatory cytokines. TRAF6 has E3 ligase activity and is responsible for inducing Lys-63 (K63)-linked poly-ubiquitination chains, functioning together with E2 Ubc13/Uev1A complex to mediate IKK activation TRAF6 plays a crucial role in the regulation of the innate and adaptive immune responses.
Publications
Species | Application | Title |
---|---|---|
Cancer Gene Ther SPHK1 potentiates colorectal cancer progression and metastasis via regulating autophagy mediated by TRAF6-induced ULK1 ubiquitination |