Validation Data Gallery
Tested Applications
Recommended dilution
| Application | Dilution |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Product Information
84929-6-PBS targets TYRO3 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Immunogen | TYRO3 fusion protein Ag29527 相同性解析による交差性が予測される生物種 |
| Full Name | TYRO3 protein tyrosine kinase |
| Calculated molecular weight | 97 kDa |
| Observed molecular weight | 130 kDa |
| GenBank accession number | BC049368 |
| Gene Symbol | TYRO3 |
| Gene ID (NCBI) | 7301 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purfication |
| UNIPROT ID | Q06418 |
| Storage Buffer | PBS Only |
| Storage Conditions | Store at -80°C. |
Background Information
TYRO3 has a structure includes a cytoplasmic domain and an extracellular ligand binding region. And ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. TYRO3 is associated with many physiological processes including cell survival, migration and differentiation. It has been reported that TYRO3 can be expressed in various regions of the mammalian central nervous system. The molecular mass of TYRO3 is 130 kDa, the apparent molecular mass is higher due to glycosylation.((PMID: 8873131, 23354874, 21539887)