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  • KD/KO Validated

UHMK1 Polyclonal antibody

UHMK1 Polyclonal Antibody for WB, IHC, IP, ELISA
Cat No. 11624-1-AP

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IHC, IF, IP, ELISA

Serine/threonine-protein kinase Kist, P-CIP2, PAM COOH-terminal interactor protein 2, KIST, KIS

Formulation:  PBS and Azide
PBS and Azide
Conjugate:  Unconjugated
Unconjugated
Size/Concentration: 

-/ -


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国内在庫・納期について

約2万点のプロテインテック製品をコスモバイオ社物流センター(国内)に在庫しています。国内在庫の有無はコスモバイオ社ホームページの「品番検索」でカタログ番号を検索して確認できます。


保証・サポートについて

テクニカルサポートまたはご購入後1年間の交換/補填対応を承ります。詳細はこちらをご覧ください。


Tested Applications

Positive WB detected inmouse thymus tissue
Positive IP detected inmouse brain tissue
Positive IHC detected inhuman stomach tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:2000-1:16000
Immunoprecipitation (IP)IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate
Immunohistochemistry (IHC)IHC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

11624-1-AP targets UHMK1 in WB, IHC, IF, IP, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivityhuman, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen UHMK1 fusion protein Ag2204 相同性解析による交差性が予測される生物種
Full Name U2AF homology motif (UHM) kinase 1
Calculated molecular weight 419 aa, 47 kDa
Observed molecular weight 47 kDa
GenBank accession numberBC026046
Gene Symbol UHMK1
Gene ID (NCBI) 127933
RRIDAB_2214267
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ8TAS1
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

UHMK1, also named as KIS, or KIST, is a 419 amino acid protein, which contains one RRM (RNA recognition motif) domain, one protein kinase domain, and belongs to the protein kinase superfamily. UHMK1 is widely expressed, with highest levels in skeletal muscle, kidney, placenta and peripheral blood leukocytes. UHMK1 localizes in the nucleus and upon serum stimulation, phosphorylating CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. UHMK1 may be involved in trafficking and/or processing of RNA and may have a role in the developing nervous system and the adult brain.

Protocols

Product Specific Protocols
WB protocol for UHMK1 antibody 11624-1-APDownload protocol
IHC protocol for UHMK1 antibody 11624-1-APDownload protocol
IP protocol for UHMK1 antibody 11624-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
ratIHC

Brain Res

Cord blood administration induces oligodendrocyte survival through alterations in gene expression.

Authors - Rowe D D DD
humanWB,IHC,IF

Cell Death Dis

UHMK1 aids colorectal cancer cell proliferation and chemoresistance through augmenting IL-6/STAT3 signaling.

Authors - Xuedi Gao
  • KD Validated
humanWB

Thorac Cancer

UHMK1 promotes lung adenocarcinoma oncogenesis by regulating the PI3K/AKT/mTOR signaling pathway

Authors - Yongmeng Li
  • KD Validated
humanWB,IHC

J Cancer Res Clin Oncol

KIS, a target of SOX4, regulates the ID1-mediated enhancement of β-catenin to facilitate lung adenocarcinoma cell proliferation and metastasis

Authors - Jing-Xia Chang
  • KD Validated
humanWB,IHC

Oral Surg Oral Med Oral Pathol Oral Radiol

Expression and clinical significance of U2AF homology motif kinase 1 in oral squamous cell carcinoma

Authors - Xuan Zhang
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