WHSC1 Polyclonal antibody, PBS Only
WHSC1 Polyclonal Antibody for WB, IHC, IP, Indirect ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human
Applications
WB, IHC, IP, Indirect ELISA
Conjugate
Unconjugated
Cat no : 22722-1-PBS
Synonyms
Validation Data Gallery
Tested Applications
Recommended dilution
Application | Dilution |
---|---|
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. |
Product Information
22722-1-PBS targets WHSC1 in WB, IHC, IP, Indirect ELISA applications and shows reactivity with human samples.
Tested Reactivity | human |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | WHSC1 fusion protein Ag18611 相同性解析による交差性が予測される生物種 |
Full Name | Wolf-Hirschhorn syndrome candidate 1 |
Calculated molecular weight | 162 kDa |
Observed molecular weight | 70 kDa, 150 kDa |
GenBank accession number | BC152412 |
Gene symbol | WHSC1 |
Gene ID (NCBI) | 7468 |
RRID | AB_2879156 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Antigen Affinity purified |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
WHSC1 (also known as MMSET or NSD2) is a SET domain containing histone lysine methyltransferase that can di- and trimethylate histone H3 at lysine 36 (H3K36). WHSC1 mRNA is highly expressed in embryonic tissues, especially those with high degrees of proliferation, whereas in adult tissues,the mRNA is primarily expressed in thymus and testis. WHSC1 is implicated in cellular adhesion, clonogenic growth and tumorigenicity. Its overexpression has been found in various cancers. It undergoes alternative splicing resulting in different protein isoforms. Recently WHSC1 has been identified as a critical epigenetic regulator for Tfh differentiation.