Validation Data Gallery
Tested Applications
Recommended dilution
| Application | Dilution |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Product Information
67274-1-PBS targets WWP2 in WB, IHC, Indirect ELISA applications and shows reactivity with Human, Rat samples.
| Tested Reactivity | Human, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen | WWP2 fusion protein Ag2835 相同性解析による交差性が予測される生物種 |
| Full Name | WW domain containing E3 ubiquitin protein ligase 2 |
| Calculated molecular weight | 870 aa, 99 kDa |
| Observed molecular weight | 100-115 kDa |
| GenBank accession number | BC013645 |
| Gene Symbol | WWP2 |
| Gene ID (NCBI) | 11060 |
| RRID | AB_2882543 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein G purification |
| UNIPROT ID | O00308 |
| Storage Buffer | PBS Only |
| Storage Conditions | Store at -80°C. |
Background Information
WWP2 (WW domain-containing protein 2) is also named as AIP2 and belongs to the NEDD4-like protein family. It functions as an E3 ubiquitin ligase for PTEN that plays a vital role in tumour-cell survival and is also involved in regulating transcription, embryonic stem-cell fate, cellular transport and T-cell activation processes (PMID:21532586). WWP2, which specifically interacted with ES cell-specific transcription factor Oct-4 and promoted its ubiquitination both in vitro and in vivo, is a ubiquitously expressed protein and exists in both cytoplasmic and nuclear compartments in ES cells (PMID:15047715).