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- KD/KO Validated
YEATS2 Polyclonal antibody
YEATS2 Polyclonal Antibody for WB, IP, IHC, ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human and More (1)
Applications
WB, IP, IHC, ELISA
Conjugate
Unconjugated
Cat no : 24717-1-AP
Synonyms
Validation Data Gallery
Tested Applications
| Positive WB detected in | Jurkat cells |
| Positive IP detected in | Jurkat cells |
| Positive IHC detected in | human cervical cancer tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
Recommended dilution
| Application | Dilution |
|---|---|
| Western Blot (WB) | WB : 1:200-1:1000 |
| Immunoprecipitation (IP) | IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate |
| Immunohistochemistry (IHC) | IHC : 1:20-1:200 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
Published Applications
| KD/KO | See 3 publications below |
| WB | See 6 publications below |
| IHC | See 4 publications below |
| IP | See 1 publications below |
Product Information
24717-1-AP targets YEATS2 in WB, IP, IHC, ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Cited Reactivity | human, mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | YEATS2 fusion protein Ag20134 相同性解析による交差性が予測される生物種 |
| Full Name | YEATS domain containing 2 |
| Calculated molecular weight | 1422 aa, 151 kDa |
| Observed molecular weight | 151 kDa |
| GenBank accession number | BC150273 |
| Gene symbol | YEATS2 |
| Gene ID (NCBI) | 55689 |
| RRID | AB_2879686 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
Background Information
YEATS domain containing 2 (YEATS2) protein is a scaffolding subunit of the ATAC complex. Studies have shown that YEATS2 is a selective histone crotonylation reader and is related to histone acetylation. In addition, YEATS2 is associated with the progression of various tumors. Overexpression of YEATS2 promotes the proliferation and migration of pancreatic cancer cells. YEATS2 has been reported to be associated with the progression of non-small-cell lung cancer through histone acetylation.
Protocols
| Product Specific Protocols | |
|---|---|
| WB protocol for YEATS2 antibody 24717-1-AP | Download protocol |
| IHC protocol for YEATS2 antibody 24717-1-AP | Download protocol |
| IP protocol for YEATS2 antibody 24717-1-AP | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
Publications
| Species | Application | Title |
|---|---|---|
Nat Commun YEATS2 links histone acetylation to tumorigenesis of non-small cell lung cancer.
| ||
Cell Biol Toxicol YEATS2 regulates the activation of TAK1/NF-κB pathway and is critical for pancreatic ductal adenocarcinoma cell survival.
| ||
J Cell Physiol YEATS2 is a target of HIF1α and promotes pancreatic cancer cell proliferation and migration.
| ||
Signal Transduct Target Ther Multi-omic characterization of genome-wide abnormal DNA methylation reveals diagnostic and prognostic markers for esophageal squamous-cell carcinoma. | ||
Phytomedicine Cinobufacini retards progression of pancreatic ductal adenocarcinoma through targeting YEATS2/TAK1/NF-κB axis | ||
Cancers (Basel) Overexpression of YEATS2 Remodels the Extracellular Matrix to Promote Hepatocellular Carcinoma Progression via the PI3K/AKT Pathway |
