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  • KD/KO Validated

ZNF746 Polyclonal antibody

ZNF746 Polyclonal Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IF, IHC, ELISA

Conjugate

Unconjugated

Cat no : 24543-1-AP

Synonyms

PARIS, zinc finger protein 746, ZNF746


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Tested Applications

Positive WB detected inHEK-293 cells, HEK-293T cells

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:1000-1:8000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

24543-1-AP targets ZNF746 in WB, IF, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivity human, rat, mouse
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen ZNF746 fusion protein Ag21566 相同性解析による交差性が予測される生物種
Full Name zinc finger protein 746
Calculated molecular weight 644 aa, 69 kDa
Observed molecular weight 85-95 kDa
GenBank accession numberBC068505
Gene symbol ZNF746
Gene ID (NCBI) 155061
RRIDAB_2879598
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

ZNF746, also named as PARIS, which belongs to the krueppel C2H2-type zinc-finger protein family. ZNF746 mainly localizes to the cytoplasm and probably translocates to the nucleus to repress selected genes. ZNF746 as a transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death. ZNF746 may act as a downstream effector of PRKN and contribute to neurodegeneration in Parkinson disease cases caused by defects in PRKN (PMID: 28122242). The calculated molecular weight of ZNF746 is 69 kDa, but Phosphorylation of ZNF746 is about 80-85 kDa (PMID: 28122242).

Protocols

Product Specific Protocols
WB protocol for ZNF746 antibody 24543-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
mouseWB

Neuron

Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson's disease.

Authors - Nikhil Panicker
  • KO Validated
human,mouseWB

Sci Adv

Deubiquitinase CYLD acts as a negative regulator of dopamine neuron survival in Parkinson's disease.

Authors - Sheila K Pirooznia
mouseWB

Brain

Parkin interacting substrate zinc finger protein 746 is a pathological mediator in Parkinson's disease.

Authors - Saurav Brahmachari
human,mouseWB,IF

Brain

Parkin interacting substrate phosphorylation by c-Abl drives dopaminergic neurodegeneration.

Authors - Hyojung Kim
mouseWB

Front Aging Neurosci

Identification and evaluation of midbrain specific longevity-related genes in exceptionally long-lived but healthy mice

Authors - Hyojung Kim
human,mouseWB,IHC

Biochem Biophys Res Commun

ZNF746/PARIS promotes the occurrence of hepatocellular carcinoma.

Authors - Hanna Kim
  • KO Validated