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Mouse p21 Monoclonal antibody, PBS Only

p21 Monoclonal Antibody for IF/ICC, ELISA
Cat No. 67362-1-PBS
Clone No.3C7D3

Host / Isotype

Mouse / IgG2b

Reactivity

mouse

Applications

IF/ICC, ELISA

Cdkn1a, p21WAF, p21Cip1, P21 protein, Cdkn1

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -


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国内在庫・納期について

約2万点のプロテインテック製品をコスモバイオ社物流センター(国内)に在庫しています。国内在庫の有無はコスモバイオ社ホームページの「品番検索」でカタログ番号を検索して確認できます。


保証・サポートについて

テクニカルサポートまたはご購入後1年間の交換/補填対応を承ります。詳細はこちらをご覧ください。


Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

67362-1-PBS targets p21 in IF/ICC, ELISA applications and shows reactivity with mouse samples.

Tested Reactivity mouse
Host / Isotype Mouse / IgG2b
Class Monoclonal
Type Antibody
Immunogen p21 fusion protein Ag28394 相同性解析による交差性が予測される生物種
Full Name cyclin-dependent kinase inhibitor 1A (P21)
Calculated molecular weight 18 kDa
GenBank accession numberNM_001111099
Gene Symbol p21
Gene ID (NCBI) 12575
RRIDAB_2882614
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDP39689
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

CDKN1A (p21, CIP1, WAF1) is a cyclin-dependent kinase inhibitor. CDKN1A binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at the G1 phase. The expression of CDKN1A is induced by wild-type but not mutant p53 protein, through which CDKN1A mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. CDKN1A can interact with proliferating cell nuclear antigen (PCNA), and plays a regulatory role in S phase DNA replication and DNA damage repair. CDKN1A was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation.

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