• HEK293 expressed
  • Endotoxin-free
  • Animal-component free

HumanKine® recombinant human Noggin protein

Activity

1.5-15 ng/mL

Species Reactivity

human,mouse

Purity

>95%

Cat no : HZ-1118

Synonyms

NOG, noggin, SYM1, SYNS1



Technical Specifications

GeneID 9241
Species Human
Expression HEK293
Activity 1.5-15 ng/mL
Purity >95%
Endotoxin<1 EU/μg
Accession NumberQ13253
Molecular Mass 28 kDa reduced, 50 to 95 kDa non-reduced, homodimer, glycosylated
Formulation 1x PBS, See Certificate of Analysis for details
Species Reactivity human,mouse

Stability and Reconstitution

Stability and Storage Lyophilized proteins are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.
Reconstitution Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein to 0.2 mg/mL in sterile 1xPBS pH 7.4 containing 0.1% endotoxin-free recombinant human serum albumin (HSA). Gently swirl or tap vial to mix.

Background

Noggin is an inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. It is essential for cartilage morphogenesis and joint formation. Noggin inhibits chondrocyte differentiation through its interaction with GDF5 and GDF6 (PMID: 29497255; 29167826; 29094227; 28842965).

Synonyms

NOG, noggin, SYM1, SYNS1

Publications

SpeciesTitle

Cell Stem Cell

Increased Neural Progenitor Proliferation in a hiPSC Model of Autism Induces Replication Stress-Associated Genome Instability.

Authors - Meiyan Wang
human

Nat Methods

Long-term expansion of alveolar stem cells derived from human iPS cells in organoids.

Authors - YukiYamamoto
human

Cell Stem Cell

Efficient Generation of CA3 Neurons from Human Pluripotent Stem Cells Enables Modeling of Hippocampal Connectivity In Vitro.

Authors - Anindita Sarkar
mouse

Nat Commun

Pharmacological blockade of TEAD–YAP reveals its therapeutic limitation in cancer cells

Authors - Yang Sun
human

Biomaterials

Core-shell hydrogel microfiber-expanded pluripotent stem cell-derived lung progenitors applicable to lung reconstruction in vivo.

Authors - Satoshi Ikeo
human

Curr Biol

Human-specific regulation of neural maturation identified by cross-primate transcriptomics

Authors - Sara B Linker