- HEK293 expressed
- Endotoxin-free
- Animal-component free
HumanKine® recombinant human TGF beta 1 protein
Cat no : HZ-1011
Synonyms
CED, DPD1, LAP, TGF B1, TGF beta 1, tgf beta1, TGFB, TGFB1, TGFbeta, tgf-beta1
Validation Data Gallery
Technical Specifications
GeneID | 7040 |
Species | Human |
Expression | HEK293 |
Activity | Typically ≤ 0.5 ng/mL EC50 |
Purity | >95% |
Endotoxin | <1 EU/µg |
Accession Number | P01137 |
Molecular Mass | 25 kDa, homodimer, nonglycosylated |
Formulation | 50 mM NaOAc pH 4.5, See Certificate of Analysis for details |
Species Reactivity | human,mouse |
Stability and Reconstitution
Stability and Storage | Lyophilized proteins are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products. |
Reconstitution | Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 4 mM HCl containing 0.1% endotoxin-free recombinant human serum albumin (HSA). |
Background
TGFB, also named as LAP and TGFB1, is a multifunctional peptide that controls proliferation, and cell differentiation. TGF acts synergistically with TGFA in inducing transformation process. It also acts as a negative autocrine growth factor. Dysregulation of TGFB activation and signaling may result in apoptosis. Many cells synthesize TGFB having specific receptors for it. TGFB positively and negatively regulates many other growth factors. It plays an important role in bone remodeling being a potent stimulator of an osteoblastic bone formation (PMID: 11586292).
Synonyms
CED, DPD1, LAP, TGF B1, TGF beta 1, tgf beta1, TGFB, TGFB1, TGFbeta, tgf-beta1
Publications
Species | Title |
---|---|
J Biol Chem Transforming growth factor β (TGF-β)-induced up-regulation of TGF-β receptors at the cell surface amplifies the TGF-β response. | |
Protein Cell Telomere-dependent and telomere-independent roles of RAP1 in regulating human stem cell homeostasis. | |
Immunity A Mutation in the Transcription Factor Foxp3 Drives T Helper 2 Effector Function in Regulatory T Cells. | |
J Cell Biochem microRNA-539 functions as a tumor suppressor in papillary thyroid carcinoma via the transforming growth factor β1/Smads signaling pathway by targeting secretory leukocyte protease inhibitor. | |
Cell Stem Cell FOXO3-Engineered Human ESC-Derived Vascular Cells Promote Vascular Protection and Regeneration. |