ABL1 Monoclonal antibody, PBS Only
ABL1 Monoclonal Antibody for WB, IF/ICC, FC (Intra), Indirect ELISA
Host / Isotype
Mouse / IgG2b
Reactivity
human
Applications
WB, IF/ICC, FC (Intra), Indirect ELISA
Conjugate
Unconjugated
CloneNo.
1E7A5
Cat no : 68254-1-PBS
Synonyms
Validation Data Gallery
Tested Applications
Recommended dilution
Application | Dilution |
---|---|
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. |
Product Information
68254-1-PBS targets ABL1 in WB, IF/ICC, FC (Intra), Indirect ELISA applications and shows reactivity with human samples.
Tested Reactivity | human |
Host / Isotype | Mouse / IgG2b |
Class | Monoclonal |
Type | Antibody |
Immunogen | ABL1 fusion protein Ag26152 相同性解析による交差性が予測される生物種 |
Full Name | c-abl oncogene 1, receptor tyrosine kinase |
Calculated molecular weight | 123 kDa |
Observed molecular weight | 140 kDa |
GenBank accession number | NM_005157 |
Gene symbol | ABL1 |
Gene ID (NCBI) | 25 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
ABL1, also named as ABL, JTK7, c-ABL and p150, belongs to the protein kinase superfamily, Tyr protein kinase family and ABL subfamily. ABL1 regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. ABL1 localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. It regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. ABL1 catalyze the reaction: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. A chromosomal aberration involving ABL1 is a cause of chronic myeloid leukemia (CML) [MIM:608232]. Translocation t(9;22)(q34;q11) with BCR. The translocation produces a BCR-ABL found also in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). The antibody is specific to ABL1.