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ACVRL1 Monoclonal antibody

ACVRL1 Monoclonal Antibody for WB, IHC, ELISA
Cat No. 66857-1-Ig
Clone No.2E11B10

Host / Isotype

Mouse / IgG1

Reactivity

Human, Mouse

Applications

WB, IHC, ELISA

Activin receptor like kinase 1, ACVRL1, ACVRLK1, ALK 1, ALK1, HHT, HHT2, ORW2, SKR3, TSR I

Formulation:  PBS and Azide
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Unconjugated
Size/Concentration: 

-/ -


ご購入について

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国内在庫・納期について

約2万点のプロテインテック製品をコスモバイオ社物流センター(国内)に在庫しています。国内在庫の有無はコスモバイオ社ホームページの「品番検索」でカタログ番号を検索して確認できます。


保証・サポートについて

テクニカルサポートまたはご購入後1年間の交換/補填対応を承ります。詳細はこちらをご覧ください。


Tested Applications

Positive WB detected inHUVEC cells, Daudi cells, human placenta tissue, JAR cells, Jurkat cells, mouse brain tissue
Positive IHC detected inhuman lymphoma tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:1000-1:6000
Immunohistochemistry (IHC)IHC : 1:150-1:600
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

66857-1-Ig targets ACVRL1 in WB, IHC, ELISA applications and shows reactivity with Human, Mouse samples.

Tested Reactivity Human, Mouse
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen ACVRL1 fusion protein Ag6446 相同性解析による交差性が予測される生物種
Full Name activin A receptor type II-like 1
Calculated molecular weight 56 kDa
Observed molecular weight 56 kDa, 63 kDa
GenBank accession numberBC042637
Gene Symbol ACVRL1
Gene ID (NCBI) 94
RRIDAB_2882196
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDP37023
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

ACVRL1 (also known as ALK1) is a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. ACVRL1 is highly expressed in endothelial cells and has a critical role in the control of blood vessel development and repair (PMID: 8640225). Mutations in the ACVRL1 gene are associated with hemorrhagic telangiectasia type 2.

Protocols

Product Specific Protocols
WB protocol for ACVRL1 antibody 66857-1-IgDownload protocol
IHC protocol for ACVRL1 antibody 66857-1-IgDownload protocol
Standard Protocols
Click here to view our Standard Protocols
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