ADAM17 Monoclonal antibody, PBS Only
ADAM17 Monoclonal Antibody for WB, Indirect ELISA
Host / Isotype
Mouse / IgG1
Reactivity
Human, Mouse
Applications
WB, Indirect ELISA
Conjugate
Unconjugated
CloneNo.
2F4C2
Cat no : 68725-1-PBS
Synonyms
Validation Data Gallery
Tested Applications
Recommended dilution
Application | Dilution |
---|---|
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. |
Product Information
68725-1-PBS targets ADAM17 in WB, Indirect ELISA applications and shows reactivity with Human, Mouse samples.
Tested Reactivity | Human, Mouse |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Immunogen | ADAM17 fusion protein Ag34022 相同性解析による交差性が予測される生物種 |
Full Name | ADAM metallopeptidase domain 17 |
Calculated molecular weight | 824 aa, 93 kDa |
Observed molecular weight | 90-110 kDa |
GenBank accession number | BC136783 |
Gene symbol | ADAM17 |
Gene ID (NCBI) | 6868 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein G purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
The ADAMs (A Disintegrin And Metalloprotease) are multidomain transmembrane proteins. One of the first ADAMs implicated in membrane shedding is ADAM-17, which is shown to release the active form of tumor necrosis factor (TNF)-a from its precursor (PMID:18238782). ADAM17 is also named as CSVP, TACE. The full length protein has 9 glycosylation sites, a signal peptide, propeptide and 2 isoforms produced by alternative splicing.The 120-kDa form of ADAM-17 is expressed more frequently and at higher levels in primary breast carcinomas compared with normal breast tissue(PMID:17438092).