AGT Monoclonal antibody, PBS Only
AGT Monoclonal Antibody for WB, IHC, IF/ICC, Indirect ELISA
Host / Isotype
Mouse / IgG2b
Reactivity
Human, pig
Applications
WB, IHC, IF/ICC, Indirect ELISA
Conjugate
Unconjugated
CloneNo.
1B2F5
Cat no : 68020-1-PBS
Synonyms
Validation Data Gallery
Tested Applications
Recommended dilution
Application | Dilution |
---|---|
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. |
Product Information
68020-1-PBS targets AGT in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with Human, pig samples.
Tested Reactivity | Human, pig |
Host / Isotype | Mouse / IgG2b |
Class | Monoclonal |
Type | Antibody |
Immunogen | AGT fusion protein Ag16658 相同性解析による交差性が予測される生物種 |
Full Name | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) |
Calculated molecular weight | 485 aa, 53 kDa |
Observed molecular weight | 52 kDa |
GenBank accession number | BC011519 |
Gene symbol | AGT |
Gene ID (NCBI) | 183 |
RRID | AB_2918765 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
Angiotensinogen is a precursor of angiotensin II (Ang II), is expressed and synthesized largely in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. It has a key role in mediating vascular constriction and regulating salt and fluid homeostasis. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene also have been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.