Validation Data Gallery
Tested Applications
Recommended dilution
| Application | Dilution |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Product Information
66619-1-PBS targets Adiponectin receptor 1 in WB, Indirect ELISA applications and shows reactivity with Human samples.
| Tested Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen | Adiponectin receptor 1 fusion protein Ag18187 相同性解析による交差性が予測される生物種 |
| Full Name | adiponectin receptor 1 |
| Calculated molecular weight | 375 aa, 43 kDa |
| Observed molecular weight | 43 kDa |
| GenBank accession number | BC010743 |
| Gene Symbol | Adiponectin receptor 1 |
| Gene ID (NCBI) | 51094 |
| RRID | AB_2881979 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein G purification |
| UNIPROT ID | Q96A54 |
| Storage Buffer | PBS only , pH 7.3 |
| Storage Conditions | Store at -80°C. |
Background Information
Adiponectin is a hormone secreted by adipocytes that acts as an antidiabetic and anti-atherogenic adipokine. Two receptors for adiponectin have been identified: adiponectin receptor 1 (AdipoR1) and adiponectin receptor 2 (AdipoR2). They are seven-transmembrane domain receptors and mediate increased AMPK, MAPK and PPARA ligand activity in response to adiponectin. AdipoR1 is found in many tissues, being particularly abundant in skeletal muscle, whereas AdipoR2 is predominantly expressed in the liver (PMID: 24417942). AdipoR1 has a high affinity for globular adiponectin and a very low affinity for full-length adiponectin. AdipoR2 has an intermediate affinity for both forms. The human ADIPOR1 gene maps to chromosome 1q32.1, and encodes a 375-amino acid protein with a molecular weight of 43 kDa. This antibody was raised against 1-72aa of human AdipoR1.