FITC Plus Anti-Human CD107a / LAMP1 (H4A3) Rabbit IgG Recombinant Antibody
CD107a / LAMP1 Recombinant Antibody for FC (Intra)
Host / Isotype
Rabbit / IgG
Reactivity
Human
Applications
FC (Intra)
Conjugate
FITC Plus Fluorescent Dye
CloneNo.
H4A3
Cat no : FITC-65549
Synonyms
Validation Data Gallery
Tested Applications
| Positive FC (Intra) detected in | Jurkat cells |
| Positive FC detected in | jurkat cells |
Recommended dilution
| Application | Dilution |
|---|---|
| This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 µl per 10^6 cells in a 100 µl suspension or 5 µl per 100 µl of whole blood. | |
| Sample-dependent, Check data in validation data gallery. | |
Product Information
FITC-65549 targets CD107a / LAMP1 in FC (Intra) applications and shows reactivity with Human samples.
| Tested Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Immunogen | Human adherent peripheral blood cells 相同性解析による交差性が予測される生物種 |
| Full Name | lysosomal-associated membrane protein 1 |
| GenBank accession number | BC006345 |
| Gene symbol | LAMP1 |
| Gene ID (NCBI) | 3916 |
| Conjugate | FITC Plus Fluorescent Dye |
| Excitation/Emission maxima wavelengths | 495 nm / 524 nm |
| Form | Liquid |
| Purification Method | Affinity purification |
| Storage Buffer | PBS with 0.09% sodium azide and 0.5% BSA. |
| Storage Conditions | Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment. |
Background Information
LAMP1 (CD107a) is a heavily glycosylated membrane protein enriched in the lysosomal membrane. LAMP1 is extensively glycosylated with asparagine-linked oligosaccharides which protect it from intracellular proteolysis (PMID: 10521503). Although LAMP1 is expressed largely in the endosome-lysosomal membrane of cells, it is also found on the plasma membrane (PMID: 16168398). Elevated LAMP1 expression at the cell surface has also been detected during platelet and granulocytic cell activation, as well as in some tumor cells (PMID: 29085473). LAMP1 functions to provide selectins with carbohydrate ligands. This protein has also been shown to be a marker of degranulation on lymphocytes such as CD8+ and NK cells and may also play a role in tumor cell differentiation and metastasis (PMID: 18835598; 29085473; 9426697).
Protocols
| Product Specific Protocols | |
|---|---|
| FC protocol for FITC Plus CD107a / LAMP1 antibody FITC-65549 | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
