CoraLite® Plus 488 Anti-Human CD11c (BU15) Mouse IgG2a Recombinant Antibody
CD11c Recombinant Antibody for FC
Host / Isotype
Mouse / IgG2a
Reactivity
human
Applications
FC
Conjugate
CoraLite® Plus 488 Fluorescent Dye
CloneNo.
BU15
Cat no : CL488-65600
Synonyms
Validation Data Gallery
Tested Applications
Positive FC detected in | human peripheral blood leukocytes |
Recommended dilution
Application | Dilution |
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This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 µl per 10^6 cells in a 100 µl suspension or 5 µl per 100 µl of whole blood. | |
Sample-dependent, Check data in validation data gallery. |
Product Information
CL488-65600 targets CD11c in FC applications and shows reactivity with human samples.
Tested Reactivity | human |
Host / Isotype | Mouse / IgG2a |
Class | Recombinant |
Type | Antibody |
Immunogen | Human synovial fluid dendritic cells 相同性解析による交差性が予測される生物種 |
Full Name | integrin, alpha X (complement component 3 receptor 4 subunit) |
Calculated molecular weight | 1169 aa, 129 kDa |
GenBank accession number | BC038237 |
Gene symbol | CD11c |
Gene ID (NCBI) | 3687 |
Conjugate | CoraLite® Plus 488 Fluorescent Dye |
Excitation/Emission maxima wavelengths | 493 nm / 522 nm |
Form | Liquid |
Purification Method | Protein A purification |
Storage Buffer | PBS with 0.09% sodium azide and 0.5% BSA. |
Storage Conditions | Store at 2-8°C. Avoid exposure to light. |
Background Information
Integrins are cell adhesion receptors that are heterodimers composed of non-covalently associated α and β subunits (PMID: 9779984). CD11c, also known as integrin αX, is a type I transmembrane glycoprotein present on a variety of cells, including monocytes/macrophages, granulocytes, a subset of B cells, NK cells and dendritic cells (PMID: 2897326; 1680915; 1694698; 17389580). As a result of its high level of expression on most dendritic cells, CD11c is typically considered to be a marker of conventional dendritic cells (PMID: 27119555). CD11c forms an α/β heterodimer with CD18 (integrin β2). CD11c/CD18 acts as a receptor for fibrinogen and is important in monocyte adhesion and chemotaxis (PMID: 1671533).
Protocols
Product Specific Protocols | |
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FC protocol for CL Plus 488 CD11c antibody CL488-65600 | Download protocol |
Standard Protocols | |
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Click here to view our Standard Protocols |