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Recommended dilution
| Application | Dilution |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Product Information
21978-1-PBS targets CHRM3 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | CHRM3 fusion protein Ag17791 相同性解析による交差性が予測される生物種 |
| Full Name | cholinergic receptor, muscarinic 3 |
| Calculated molecular weight | 590 aa, 66 kDa |
| Observed molecular weight | 60-66 kDa |
| GenBank accession number | BC121026 |
| Gene Symbol | CHRM3 |
| Gene ID (NCBI) | 1131 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | P20309 |
| Storage Buffer | PBS Only |
| Storage Conditions | Store at -80°C. |
Background Information
CHRM3 (M3 muscarinic acetylcholine receptor) is a major player in many kinds of cancer (PMID: 26175851). The expression of muscarinic receptors, mainly the CHRM3, is amplified in several types of tumors, including colon cancer, prostate cancer, endometrial carcinoma, and gastric cancer. Colon cancer overexpresses CHRM3, and post-M3R signaling promotes cell growth via the activation of the epidermal growth factor receptors/ERK and protein kinase C/p38 mitogen-activated protein kinase (MAPK) signaling pathways (PMID: 37744266).