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  • Featured Product
  • KD/KO Validated

CHRNA7/CHRFAM7A Polyclonal antibody, PBS Only

CHRNA7/CHRFAM7A Polyclonal Antibody for WB, Indirect ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

Cat no : 21586-1-PBS

Synonyms

Validation Data Gallery

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  • Western Blot (WB) analysis of Jurkat cells using CHRNA7/CHRFAM7A Polyclonal antibody (21586-1-AP)

    WB analysis of Jurkat using 21586-1-AP (same clone as 21586-1-PBS)

    Jurkat cells were subjected to SDS PAGE followed by western blot with 21586-1-AP (CHRNA7/CHRFAM7A antibody) at dilution of 1:200 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 21586-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of Jurkat cells using CHRNA7/CHRFAM7A Polyclonal antibody (21586-1-AP)

    WB analysis of Jurkat using 21586-1-AP (same clone as 21586-1-PBS)

    WB result of CHRNA7/CHRFAM7A antibody (21586-1-AP; 1:400; incubated at room temperature for 1.5 hours) with sh-Control and sh-CHRNA7/CHRFAM7A transfected Jurkat cells. This data was developed using the same antibody clone with 21586-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of Jurkat cells using CHRNA7/CHRFAM7A Polyclonal antibody (21586-1-AP)

    WB analysis of Jurkat using 21586-1-AP (same clone as 21586-1-PBS)

    Jurkat cells were subjected to SDS PAGE followed by western blot with 21586-1-AP (CHRNA7/CHRFAM7A antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 21586-1-PBS in a different storage buffer formulation.

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Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

21586-1-PBS targets CHRNA7/CHRFAM7A in WB, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen CHRNA7/CHRFAM7A fusion protein Ag16151 相同性解析による交差性が予測される生物種
Full Name CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion
Calculated molecular weight 412 aa, 46 kDa
Observed molecular weight 46 kDa
GenBank accession numberBC101348
Gene symbol CHRNA7/CHRFAM7A
Gene ID (NCBI) 89832
RRIDAB_10734326
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Neuronal acetylcholine receptor subunit alpha-7, encoded by the CHRNA7 gene, is involved in cognition through interneuron modulation of 4-(2-aminoethyl)benzene-1,2-diol and glutamate signaling. CHRNA7 gene is genetically linked to multiple disorders with cognitive deficits. A partial duplication of CHRNA7 (CHRFAM7A) is found in humans. CHRFAM7A gene encodes the CHRNA7-FAM7A fusion protein. Expression of CHRFAM7A has been reported in brain, peripheral blood lymphocytes (PBLs), and a broad range of epithelial cells (PMID: 21718690; 23553139; 25681457). CHRFAM7A has been associated with many neuropsychiatric disorders (PMID: 25906356; 25701707). This antibody, raised against 241-386 amino acids of human CHRFAM7A protein, recognizes both CHRNA7 and CHRFAM7A.