Validation Data Gallery
Tested Applications
Recommended dilution
| Application | Dilution |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Product Information
84705-4-PBS targets CYP51A1 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Immunogen | CYP51A1 fusion protein Ag4235 相同性解析による交差性が予測される生物種 |
| Full Name | cytochrome P450, family 51, subfamily A, polypeptide 1 |
| Calculated molecular weight | 509 aa, 57 kDa |
| Observed molecular weight | 56 kDa |
| GenBank accession number | BC032322 |
| Gene Symbol | CYP51A1 |
| Gene ID (NCBI) | 1595 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purfication |
| UNIPROT ID | Q16850 |
| Storage Buffer | PBS Only |
| Storage Conditions | Store at -80°C. |
Background Information
Lanosterol 14-alpha demethylase (cytochrome P450(51), CYP51A1) belongs to the evolutionarily conserved family of cytochrome P450 and catalyzes one of the key steps in cholesterol biosynthesis. CYP51A1 protein is targeted for degradation when exposed to nitric oxide generated under inflammatory conditions by NOS2 or released from NO donor compounds (PMID: 28830911). CYP51A1 is a prognostic marker in certain cancers, including Cervical squamous cell carcinoma, Head and neck squamous cell carcinoma, Kidney chromophobe, and Kidney renal clear cell carcinoma (PMID: 24711211).