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- KD/KO Validated
DBR1 Polyclonal antibody, PBS Only
DBR1 Polyclonal Antibody for WB, IHC, IF/ICC, IP, Indirect ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human, mouse
Applications
WB, IHC, IF/ICC, IP, Indirect ELISA
Conjugate
Unconjugated
Cat no : 16019-1-PBS
Synonyms
Validation Data Gallery
Tested Applications
Recommended dilution
Application | Dilution |
---|---|
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. |
Product Information
16019-1-PBS targets DBR1 in WB, IHC, IF/ICC, IP, Indirect ELISA applications and shows reactivity with human, mouse samples.
Tested Reactivity | human, mouse |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | DBR1 fusion protein Ag8830 相同性解析による交差性が予測される生物種 |
Full Name | debranching enzyme homolog 1 (S. cerevisiae) |
Calculated molecular weight | 544 aa, 62 kDa |
Observed molecular weight | 70-80 kDa |
GenBank accession number | BC009472 |
Gene symbol | DBR1 |
Gene ID (NCBI) | 51163 |
RRID | AB_2230316 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Antigen affinity purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
DBR1(Lariat debranching enzyme) hydrolyzes 2-prime-to-5-prime branched phosphodiester bonds at the branch point of excised lariat intron RNA and converts them into linear molecules. DBR1 belongs to the lariat debranching enzyme family. Inhibiton of Dbr1 can suppress TDP-43 toxicity in primary neurons, suggesting that Dbr1 could be a potential therapeutic target for ALS and related TDP-43 proteinopathies (PMID: 23104007). This protein has 2 isoforms produced by alternative splicing.