ERAP2 Monoclonal antibody
ERAP2 Monoclonal Antibody for WB, ELISA
Host / Isotype
Mouse / IgG2b
Reactivity
Human, Rat and More (1)
Applications
WB, ELISA
Conjugate
Unconjugated
CloneNo.
2B11A2
Cat no : 67477-1-Ig
Synonyms
Validation Data Gallery
Tested Applications
| Positive WB detected in | A549 cells, HeLa cells, HepG2 cells, HSC-T6 cells |
Recommended dilution
| Application | Dilution |
|---|---|
| Western Blot (WB) | WB : 1:1000-1:5000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
Published Applications
| WB | See 1 publications below |
Product Information
67477-1-Ig targets ERAP2 in WB, ELISA applications and shows reactivity with Human, Rat samples.
| Tested Reactivity | Human, Rat |
| Cited Reactivity | human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen | ERAP2 fusion protein Ag30061 相同性解析による交差性が予測される生物種 |
| Full Name | endoplasmic reticulum aminopeptidase 2 |
| Calculated molecular weight | 110 kDa |
| Observed molecular weight | 110-120 kDa |
| GenBank accession number | BC065240 |
| Gene symbol | ERAP2 |
| Gene ID (NCBI) | 64167 |
| RRID | AB_2882704 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purification |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| Storage Conditions | Store at -20°C. Aliquoting is unnecessary for -20oC storage. |
Background Information
ERAP2(Endoplasmic reticulum aminopeptidase 2) is also named as LRAP(Leukocyte-derived arginine aminopeptidase). It plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. ERAP2 can form heterodimers with ERAP1(PMID:15908954). Defects in the expression of ERAP2 may cause improper antigen processing, possibly leading to favor tumor escape from the immune surveillance. ERAP2 has the calculated molecular mass of 105-110 kDa, and apparent molecular mass of 120 kDa duo to the glycosylation.
Protocols
| Product Specific Protocols | |
|---|---|
| WB protocol for ERAP2 antibody 67477-1-Ig | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
Publications
| Species | Application | Title |
|---|---|---|
Aging (Albany NY) ERAP2 as a potential biomarker for predicting gemcitabine response in patients with pancreatic cancer |
