FBXO22 Monoclonal antibody, PBS Only

FBXO22 Monoclonal Antibody for WB, Indirect ELISA

Host / Isotype

Mouse / IgG1

Reactivity

Human

Applications

WB, Indirect ELISA

Conjugate

Unconjugated

CloneNo.

4B8A12

Cat no : 68650-1-PBS

Synonyms

F box only protein 22, F box protein 22, F box protein FBX22p44, FBX22, FBXO22, FISTC1, FLJ13986


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Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

68650-1-PBS targets FBXO22 in WB, Indirect ELISA applications and shows reactivity with Human samples.

Tested Reactivity Human
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen FBXO22 fusion protein Ag5294 相同性解析による交差性が予測される生物種
Full Name F-box protein 22
Calculated molecular weight 403 aa, 45 kDa
Observed molecular weight45 kDa
GenBank accession numberBC039024
Gene symbol FBXO22
Gene ID (NCBI) 26263
Conjugate Unconjugated
Form Liquid
Purification MethodProtein G purification
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

FBXO22, also named as FBX22, is a substrate-recognition of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. FBXO22 is a key regulator of senescence induction through ubiquitylation of p53 for degradation. FBXO22 also acts as a molecular switch for the antagonistic and agonistic actions of selective estrogen receptor modulators (SERM) and determines the sensitivity of breast cancer to SERM by ubiquitylating KDM4B complexed with unliganded or SERMs‐bound estrogen receptor (ER). (PMID: 32536008, PMID: 32249768)