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Validation Data Gallery

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  • Western Blot (WB) analysis of human testis tissue using HORMAD1 Recombinant antibody (84003-5-RR)

    WB analysis of human testis using 84003-5-RR (same clone as 84003-5-PBS)

    human testis tissue were subjected to SDS PAGE followed by western blot with 84003-5-RR (HORMAD1 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84003-5-PBS in a different storage buffer formulation.

  • Flow cytometry (FC) experiment of A549 cells using HORMAD1 Recombinant antibody (84003-5-RR)

    FC experiment of A549 using 84003-5-RR (same clone as 84003-5-PBS)

    1x10^6 A549 cells were intracellularly stained with 0.25 ug HORMAD1 Recombinant antibody (84003-5-RR, Clone:241117E3) and APC-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L)(red), or 0.25 ug Isotype Control (blue). Cells were fixed and permeabilized with True-Nuclear Transcription Factor Buffer Set. This data was developed using the same antibody clone with 84003-5-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84003-5-RR

    Affinity and Kinetic Characterization of 84003-5-RR

    Biolayer interferometry (BLl) kinetic assays of 84003-5-RR against Human HORMAD1 were performed. The affinity constant is 2.32 nM.

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HORMAD1 Recombinant antibody, PBS Only

HORMAD1 Uni-rAbTM Recombinant Antibody for WB, FC (Intra), Indirect ELISA
Cat No. 84003-5-PBS
Clone No.241117E3

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, FC (Intra), Indirect ELISA

Synonyms

NOHMA, HORMAD 1, HORMA domain-containing protein 1, CT46, 241117E3

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

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Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

84003-5-PBS targets HORMAD1 in WB, FC (Intra), Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen HORMAD1 fusion protein Ag4914 相同性解析による交差性が予測される生物種
Full Name HORMA domain containing 1
Calculated molecular weight 45 kDa
Observed molecular weight 50-55 kDa
GenBank accession numberBC047406
Gene Symbol HORMAD1
Gene ID (NCBI) 84072
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDQ86X24
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

HORMA domain-containing proteins regulate interactions between homologous chromosomes (homologs) during meiosis in a wide range of eukaryotes [PMID:21079677]. They also implicated in other processes related to crossover formation, including DSB formation, inhibition of promiscuous formation of the synaptonemal complex (SC), and the meiotic prophase checkpoint that monitors both DSB processing and SCs [PMID:19851446]. HORMAD1 first accumulates on the chromosomes during the leptotene to zygotene stages of meiotic prophase I. As germ cells progress into the pachytene stage, HORMAD1 disappears from the synapsed chromosomal regions. However, once the chromosomes desynapse during the diplotene stage, HORMAD1 again accumulates on the chromosome axis of the desynapsed homologs [PMID:19686734].