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Biotin-conjugated IL-13RA2 Polyclonal antibody
IL-13RA2 Polyclonal Antibody for IHC
Host / Isotype
Rabbit / IgG
Reactivity
human, mouse, rat
Applications
IHC
Conjugate
Biotin
Cat no : Biotin-11059
Synonyms
Validation Data Gallery
Tested Applications
| Positive IHC detected in | mouse testis tissue Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 |
Recommended dilution
| Application | Dilution |
|---|---|
| Immunohistochemistry (IHC) | IHC : 1:50-1:500 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
Product Information
Biotin-11059 targets IL-13RA2 in IHC applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | IL-13RA2 fusion protein Ag1534 相同性解析による交差性が予測される生物種 |
| Full Name | interleukin 13 receptor, alpha 2 |
| Calculated molecular weight | 380 aa, 44 kDa |
| Observed molecular weight | 65 kDa |
| GenBank accession number | BC020739 |
| Gene symbol | IL13RA2 |
| Gene ID (NCBI) | 3598 |
| RRID | AB_3672369 |
| Conjugate | Biotin |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| Storage Buffer | PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3. |
| Storage Conditions | Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
Background Information
IL13RA2, also named as IL13R and CD213a2, belongs to the type I cytokine receptor family. It binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4). IL13RA2 lacks the cytoplasmic domain for signaling, indicating that it acts as a decoy receptor. IL13RA2 gene polymorphisms have been associated with systemic sclerosis (PMID: 16981293). Overexpression of IL13RA2 gene has been reported in several types of cancer, including melanoma, lung cancer, and brain tumor, which makes it a potential immunotherapeutic target (PMID: 19895199; 24970476; 24021875).
Protocols
| Product Specific Protocols | |
|---|---|
| IHC protocol for Biotin IL-13RA2 antibody Biotin-11059 | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
