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Target

Host

Species Reactivity

Species Reactivity

Conjugate

Conjugate

IMPDH1 Recombinant antibody

IMPDH1 Recombinant Antibody for WB, ELISA

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, ELISA

Conjugate

Unconjugated

CloneNo.

242329D8

Cat no : 84913-1-RR

Synonyms

IMPDH 1, IMPD1, IMPD 1, IMP dehydrogenase 1, EC:1.1.1.205

Validation Data Gallery

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  • Western Blot (WB) analysis of Raji cells using IMPDH1 Recombinant antibody (84913-1-RR)

    WB analysis of Raji using 84913-1-RR

    Raji cells were subjected to SDS PAGE followed by western blot with 84913-1-RR (IMPDH1 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours.

  • Western Blot (WB) analysis of various lysates using IMPDH1 Recombinant antibody (84913-1-RR)

    WB analysis using 84913-1-RR

    Various lysates were subjected to SDS PAGE followed by western blot with 84913-1-RR (IMPDH1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

  • Affinity and Kinetic Characterization of 84913-1-RR

    Affinity and Kinetic Characterization of 84913-1-RR

    Biolayer interferometry (BLl) kinetic assays of 84913-1-RR against Human IMPDH1 were performed. The affinity constant is 4.41 nM.

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Tested Applications

Positive WB detected inRaji cells, HeLa cells, A431 cells

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:1000-1:8000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

84913-1-RR targets IMPDH1 in WB, ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen IMPDH1 fusion protein Ag17473 相同性解析による交差性が予測される生物種
Full Name IMP (inosine monophosphate) dehydrogenase 1
Calculated molecular weight 563 aa, 60 kDa
Observed molecular weight53-60 kDa
GenBank accession numberBC033622
Gene symbol IMPDH1
Gene ID (NCBI) 3614
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

IMPDH1(Inosine-5'-monophosphate dehydrogenase 1) is also named as IMPD1, IMP dehydrogenase 1 and belongs to the IMPDH/GMPR family. It catalyzes the rate limiting step of de novo guanine synthesis and an important target for the development of drugs with both chemotherapeutic and immunosuppressive activity. It may also have a role in the development of malignancy and the growth progression of some tumors. This protein has some isoforms produced by alternative splicing with the molecular mass of 53-65 kDa.

Protocols

Product Specific Protocols
WB protocol for IMPDH1 antibody 84913-1-RRDownload protocol
Standard Protocols
Click here to view our Standard Protocols