Validation Data Gallery
Filter:
Tested Applications
| Positive IF/ICC detected in | A549 cells |
Recommended dilution
| Application | Dilution |
|---|---|
| Immunofluorescence (IF)/ICC | IF/ICC : 1:50-1:500 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
Product Information
CL488-67663 targets IMPDH2 in IF/ICC applications and shows reactivity with Human, mouse, rat samples.
| Tested Reactivity | Human, mouse, rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen | IMPDH2 fusion protein Ag17170 相同性解析による交差性が予測される生物種 |
| Full Name | IMP (inosine monophosphate) dehydrogenase 2 |
| Calculated molecular weight | 514 aa, 56 kDa |
| Observed molecular weight | 56 kDa |
| GenBank accession number | BC012840 |
| Gene Symbol | IMPDH2 |
| Gene ID (NCBI) | 3615 |
| RRID | AB_2934558 |
| Conjugate | CoraLite® Plus 488 Fluorescent Dye |
| Excitation/Emission maxima wavelengths | 493 nm / 522 nm |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | P12268 |
| Storage Buffer | PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3. |
| Storage Conditions | Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
Background Information
IMPDH2, also named as IMPD2, belongs to the IMPDH/GMPR family. It is a rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth. It may also have a role in the development of malignancy and the growth progression of some tumors. IMPDH2 is a key enzyme in the purine nucleotide biosynthetic pathway and constitutes a pivotal biological target for immunosuppressant and antiviral drugs. (PMID:21181270)
Protocols
| Product Specific Protocols | |
|---|---|
| IF protocol for CL Plus 488 IMPDH2 antibody CL488-67663 | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |