ITM2C Monoclonal antibody
ITM2C Monoclonal Antibody for IF, ELISA
Host / Isotype
Mouse / IgG2a
Reactivity
human
Applications
IF, ELISA
Conjugate
Unconjugated
CloneNo.
2E8G11
Cat no : 60095-1-Ig
Synonyms
Validation Data Gallery
Tested Applications
| Positive IF detected in | HepG2 cells |
Recommended dilution
| Application | Dilution |
|---|---|
| Immunofluorescence (IF) | IF : 1:20-1:200 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
Published Applications
| FC | See 1 publications below |
Product Information
60095-1-Ig targets ITM2C in IF, ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Cited Reactivity | human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen | ITM2C fusion protein Ag4409 相同性解析による交差性が予測される生物種 |
| Full Name | integral membrane protein 2C |
| Calculated molecular weight | 230aa,26 kDa; 267aa,30 kDa |
| Observed molecular weight | 35 kDa |
| GenBank accession number | BC025742 |
| Gene symbol | ITM2C |
| Gene ID (NCBI) | 81618 |
| RRID | AB_2296429 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Protein A purification |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
Background Information
The Integral membrane protein 2C (ITM2C) is a type II integral transmembrane protein belonging to a family composed of at least two other members, ITM2A and ITM2B. ITM2C, often called transmembrane protein BRI3, is highly expressed in brain tissue. Yeast two-hybrid screen system revealed that BRI3 could interact with beta-secretase beta-amyloid protein converting enzyme (BACE)1 and the microtubule-destabilizing protein SCG10 (STMN2). It may play a role in TNF-induced cell death and neuronal differentiation. BRI3 was found to inhibit the various processing of amyloid precursor protein (APP) by blocking the access of alpha- and beta-secretases to APP, competitive inhibition of APP processing by BRI3 may provide a new approach to Alzheimer disease (AD) therapy and prevention.
Protocols
| Product Specific Protocols | |
|---|---|
| IF protocol for ITM2C antibody 60095-1-Ig | Download protocol |
| FC protocol for ITM2C antibody 60095-1-Ig | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
Publications
| Species | Application | Title |
|---|---|---|
NAR Genom Bioinform Joint single cell DNA-seq and RNA-seq of gastric cancer cell lines reveals rules of in vitro evolution. |
