ITM2C Monoclonal antibody, PBS Only
ITM2C Monoclonal Antibody for IF, Indirect ELISA
Host / Isotype
Mouse / IgG2a
Reactivity
human
Applications
IF, Indirect ELISA
Conjugate
Unconjugated
CloneNo.
2E8G11
Cat no : 60095-1-PBS
Synonyms
Validation Data Gallery
Tested Applications
Recommended dilution
Application | Dilution |
---|---|
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. |
Product Information
60095-1-PBS targets ITM2C in IF, Indirect ELISA applications and shows reactivity with human samples.
Tested Reactivity | human |
Host / Isotype | Mouse / IgG2a |
Class | Monoclonal |
Type | Antibody |
Immunogen | ITM2C fusion protein Ag4409 相同性解析による交差性が予測される生物種 |
Full Name | integral membrane protein 2C |
Calculated molecular weight | 230aa,26 kDa; 267aa,30 kDa |
Observed molecular weight | 35 kDa |
GenBank accession number | BC025742 |
Gene symbol | ITM2C |
Gene ID (NCBI) | 81618 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
Storage Buffer | PBS Only |
Storage Conditions | Store at -80°C. |
Background Information
The Integral membrane protein 2C (ITM2C) is a type II integral transmembrane protein belonging to a family composed of at least two other members, ITM2A and ITM2B. ITM2C, often called transmembrane protein BRI3, is highly expressed in brain tissue. Yeast two-hybrid screen system revealed that BRI3 could interact with beta-secretase beta-amyloid protein converting enzyme (BACE)1 and the microtubule-destabilizing protein SCG10 (STMN2). It may play a role in TNF-induced cell death and neuronal differentiation. BRI3 was found to inhibit the various processing of amyloid precursor protein (APP) by blocking the access of alpha- and beta-secretases to APP, competitive inhibition of APP processing by BRI3 may provide a new approach to Alzheimer disease (AD) therapy and prevention.