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  • Featured Product
  • KD/KO Validated

CoraLite® Plus 488-conjugated LRP2-Specific Polyclonal antibody

LRP2-Specific Polyclonal Antibody for IF-P

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

IF-P

Conjugate

CoraLite® Plus 488 Fluorescent Dye

Cat no : CL488-19700

Synonyms

LRP2, LRP 2, Low-density lipoprotein receptor-related protein 2, gp330, Glycoprotein 330

Validation Data Gallery

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  • Immunofluorescence (IF) / fluorescent staining of mouse kidney tissue using CoraLite® Plus 488-conjugated LRP2-Specific Polycl (CL488-19700)

    IF Staining of mouse kidney using CL488-19700

    Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded mouse kidney tissue using CoraLite® Plus 488 LRP2-Specific antibody (CL488-19700) at dilution of 1:200. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  • Immunofluorescence (IF) / fluorescent staining of mouse kidney tissue using CoraLite® Plus 488-conjugated LRP2-Specific Polycl (CL488-19700)

    IF Staining of mouse kidney using CL488-19700

    Immunofluorescent analysis of (4% PFA) fixed paraffin-embedded mouse kidney tissue using CoraLite® Plus 488 LRP2-Specific antibody (CL488-19700) at dilution of 1:200. Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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Tested Applications

Positive IF-P detected inmouse kidney tissue

Recommended dilution

ApplicationDilution
Immunofluorescence (IF)-PIF-P : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

CL488-19700 targets LRP2-Specific in IF-P applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen Peptide 相同性解析による交差性が予測される生物種
Full Name low density lipoprotein-related protein 2
Calculated molecular weight 522 kDa
Observed molecular weight 280 kDa
GenBank accession numberNM_004525
Gene symbol LRP2
Gene ID (NCBI) 4036
Conjugate CoraLite® Plus 488 Fluorescent Dye
Excitation/Emission maxima wavelengths493 nm / 522 nm
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.
Storage ConditionsStore at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

LRP2, also named as gp330 and Megalin, belongs to the LDLR family. It acts together with cubilin to mediate HDL endocytosis. LRP2 may participate in regulation of parathyroid-hormone and para-thyroid-hormone-related protein release. Defects in LRP2 are the cause of Donnai-Barrow syndrome (DBS). This antibody is specific to LRP2 and detects endogenous LRP2 with an apparent molecular weight 280 kDa, which is smaller than the predicted molecular weight (522 kDa) and probably represent a proteolytic fragment of the large glycoprotein (PMID: 16638803; 8483924).

Protocols

Product Specific Protocols
IF protocol for CL Plus 488 LRP2-Specific antibody CL488-19700Download protocol
Standard Protocols
Click here to view our Standard Protocols