METTL1 Monoclonal antibody, PBS Only
METTL1 Monoclonal Antibody for WB, ELISA
Host / Isotype
Mouse / IgG2a
Reactivity
Human, mouse, pig
Applications
WB, ELISA
Conjugate
Unconjugated
CloneNo.
2C3G7
Cat no : 68501-1-PBS
Synonyms
Validation Data Gallery
Tested Applications
Recommended dilution
Application | Dilution |
---|---|
It is recommended that this reagent should be titrated in each testing system to obtain optimal results. |
Product Information
68501-1-PBS targets METTL1 in WB, ELISA applications and shows reactivity with Human, mouse, pig samples.
Tested Reactivity | Human, mouse, pig |
Host / Isotype | Mouse / IgG2a |
Class | Monoclonal |
Type | Antibody |
Immunogen | METTL1 fusion protein Ag7055 相同性解析による交差性が予測される生物種 |
Full Name | methyltransferase like 1 |
Calculated molecular weight | 31 kDa |
Observed molecular weight | 31 kDa |
GenBank accession number | BC000550 |
Gene symbol | METTL1 |
Gene ID (NCBI) | 4234 |
Conjugate | Unconjugated |
Form | Liquid |
Purification Method | Protein A purification |
Storage Buffer | PBS only |
Storage Conditions | Store at -80°C. |
Background Information
METTL1 methyltransferase mediates m7G methylation within miRNAs and regulates cell migration via its catalytic activity. METTL1 can be inactivated by phosphorylation at Ser27 by protein kinase B (PKBα). Overexpression of METTL1 is widely observed among human cancers. It is also crucial for the regulation of chemoresistance in cancer treatment. In addition, mutations in the human N7-methylguanosine (m7G) methyltransferase complex METTL1/WDR4 cause primordial dwarfism and brain malformation.