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Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using MTHFD2 Monoclonal antibody (68524-1-Ig)

    WB analysis using 68524-1-Ig (same clone as 68524-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 68524-1-Ig (MTHFD2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 68524-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human lung cancer tissue using MTHFD2 Monoclonal antibody (68524-1-Ig)

    IHC staining of human lung cancer using 68524-1-Ig (same clone as 68524-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using 68524-1-Ig (MTHFD2 antibody) at dilution of 1:500 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 68524-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human lung cancer tissue using MTHFD2 Monoclonal antibody (68524-1-Ig)

    IHC staining of human lung cancer using 68524-1-Ig (same clone as 68524-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using 68524-1-Ig (MTHFD2 antibody) at dilution of 1:500 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 68524-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of mouse kidney tissue using MTHFD2 Monoclonal antibody (68524-1-Ig)

    IHC staining of mouse kidney using 68524-1-Ig (same clone as 68524-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse kidney tissue slide using 68524-1-Ig (MTHFD2 antibody) at dilution of 1:500 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 68524-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of mouse kidney tissue using MTHFD2 Monoclonal antibody (68524-1-Ig)

    IHC staining of mouse kidney using 68524-1-Ig (same clone as 68524-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse kidney tissue slide using 68524-1-Ig (MTHFD2 antibody) at dilution of 1:500 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 68524-1-PBS in a different storage buffer formulation.

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MTHFD2 Monoclonal antibody, PBS Only

MTHFD2 Monoclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 68524-1-PBS
Clone No.1B4B6

Host / Isotype

Mouse / IgG2a

Reactivity

Human, Mouse

Applications

WB, IHC, Indirect ELISA

Synonyms

MTHFD2

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

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テクニカルサポートまたはご購入後1年間の交換／補填対応を承ります。詳細はこちらをご覧ください。

Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

68524-1-PBS targets MTHFD2 in WB, IHC, Indirect ELISA applications and shows reactivity with Human, Mouse samples.

Tested Reactivity Human, Mouse
Host / Isotype Mouse / IgG2a
Class Monoclonal
Type Antibody
Immunogen MTHFD2 fusion protein Ag33605 相同性解析による交差性が予測される生物種
Full Name methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
Calculated molecular weight 350 aa, 38 kDa
Observed molecular weight 33-38 kDa
GenBank accession numberBC017054
Gene Symbol MTHFD2
Gene ID (NCBI) 10797
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDP13995
Storage Buffer PBS Only
Storage ConditionsStore at -80°C.

Background Information

Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) is a folate-coupled mitochondrial metabolic enzyme characterized by methylenetetrahydrofolate dehydrogenase and cyclohydrolase activity. It was demonstrated that suppression of MTHFD2 inhibits methylation reactions, decreases protein synthesis and disrupts redox homeostasis, which may ultimately result in significant changes in cellular metabolic phenotype. MTHFD2 is reported to be up‐regulated in various tumours, such as lung adenocarcinoma(PMID: 34121323) and breast cancer(PMID: 34007312).